Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a

A defect in the maternal copy of a ubiqutin ligase gene Ube3a can produce a neurodevelopmental defect in human children known as Angelman syndrome. We investigated the role of the maternally expressed Ube3a gene in experience-dependent development and plasticity of the mouse visual system. As demons...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (12), p.5611-5616
Hauptverfasser:	Sato, Masaaki, Stryker, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelman syndrome Angelman Syndrome - genetics Angelman Syndrome - physiopathology Animals Biological Sciences Dendrites Developmental disabilities Dominance, Ocular - genetics Dominance, Ocular - physiology Eyes Female Gene expression Genomic Imprinting Humans Imaging Male Mice Mice, Inbred C57BL Mice, Knockout Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurons Neurosciences Ocular dominance Rodents Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology Visual acuity Visual cortex Visual Cortex - growth & development Visual Cortex - physiology
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