Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis

Bacterial nucleoid-associated proteins play important roles in chromosome organization and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis is a unique nucleoid-associated protein that binds AT-rich regions of the genome, including genomic islands acquired by horizontal gene t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (11), p.5154-5159
Hauptverfasser:	Gordon, Blair R.G, Li, Yifei, Wang, Linru, Sintsova, Anna, van Bakel, Harm, Tian, Songhai, Navarre, William Wiley, Xia, Bin, Liu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	AT Rich Sequence - genetics Bacteria Binding sites Biological Sciences Chromatin Chromosomes Data processing Datasets Deoxyribonucleic acid DNA DNA, Bacterial - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Enterobacteriaceae Escherichia coli Gene expression regulation Gene regulation Gene silencing Genes Genes, Bacterial - genetics Genomes Genomics Islands Lipids Models, Molecular Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity N.M.R NMR Nuclear magnetic resonance Nucleotide sequence Protein Binding Protein Multimerization Protein Structure, Secondary Protein Structure, Tertiary Proteins Secretion Solutions Transcription Virulence Virulence - genetics virulence factors
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