Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

The regenerative process in the pancreas is of particular interest because diabetes results from an inadequate number of insulin-producing beta cells and pancreatic cancer may arise from the uncontrolled growth of progenitor/stem cells. Continued and substantial growth of islet tissue occurs after b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (50), p.19915-19919
Hauptverfasser:	Inada, Akari, Nienaber, Cameron, Katsuta, Hitoshi, Fujitani, Yoshio, Levine, Jared, Morita, Rina, Sharma, Arun, Bonner-Weir, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Alpha cells Animals Beta cells beta-Galactosidase - genetics Biological Sciences Carbonic Anhydrase II - biosynthesis Carbonic Anhydrase II - genetics Cell culture Cell growth Enzymes Epithelial Cells - cytology Epithelial Cells - enzymology Gene expression Genes, Reporter Humans Islets of Langerhans Islets of Langerhans - physiology Ligation Mice Mice, Transgenic Pancreas Pancreas, Exocrine - physiology Pancreatic cells Pancreatic Ducts - cytology Pancreatic Ducts - enzymology Progenitor cells Regeneration Rodents Stem Cell Transplantation Stem cells Stem Cells - cytology Stem Cells - enzymology Tissues Transgenes Type 1 diabetes mellitus Type 2 diabetes mellitus
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