NFκB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

The transcription factor NFκB is activated by phosphorylation and acetylation and plays important roles in inflammatory and immune responses in the cell. Additionally, posttranslational modification of the NFκB p65 subunit by O-linked N-acetylglucosamine (O-GlcNAc) has been reported, but the modific...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-11, Vol.105 (45), p.17345-17350
Hauptverfasser:	Yang, Won Ho, Park, Sang Yoon, Nam, Hyung Wook, Kim, Do Hyun, Kang, Jeong Gu, Kang, Eun Seok, Kim, Yu Sam, Lee, Hyun Chul, Kim, Kwan Soo, Cho, Jin Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Antibodies Biological Sciences Cellular immunity Diabetes complications Gene expression regulation Immunoblotting Phosphorylation Plasmids Transcriptional activation Type 1 diabetes mellitus
Online-Zugang:	Volltext
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