Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

Nerve growth factor (NGF) binds to TrkA receptor and triggers activation of numerous signaling cascades, which play critical roles in neuronal plasticity, survival, and neurite outgrowth. To mimic NGF functions pharmacologically, we developed a high-throughput screening assay to identify small-molec...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (41), p.16329-16334
Hauptverfasser:	Jang, Sung-Wuk, Okada, Masashi, Sayeed, Iqbal, Xiao, Ge, Stein, Donald, Jin, Peng, Ye, Keqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Amides - chemistry Amides - pharmacology Animals Apoptosis Apoptosis - drug effects Biological Sciences Cell death Cell growth Cell Line Cell lines Cerebral Infarction - drug therapy Cerebral Infarction - pathology Dimerization Hippocampus - drug effects Hippocampus - pathology MAP Kinase Signaling System - drug effects Mice Mice, Inbred C57BL Molecules Nerve Growth Factors - pharmacology Neurites Neurites - drug effects Neurites - ultrastructure Neurological disorders Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism PC12 Cells Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Rats Receptor, trkA - agonists Receptors Stroke Xanthones - chemistry Xanthones - pharmacology
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