Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release

Ca²⁺ influx into presynaptic nerve terminals activates synaptic vesicle exocytosis by triggering fast synchronous fusion and a slower asynchronous release pathway. In addition, a brief rise in Ca²⁺ after consecutive action potentials has been correlated with a form of short-term synaptic plasticity...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-08, Vol.104 (35), p.14122-14127
Hauptverfasser:	Saraswati, Sudipta, Adolfsen, Bill, Littleton, J. Troy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological Sciences Calcium Calcium - physiology Drosophila Drosophila - growth & development Drosophila - physiology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - physiology Drosophila Proteins - physiology Electrophysiology Evoked Potentials - physiology Gene Deletion Gene expression Genotypes Insects Larva - physiology Larvae Muscle, Skeletal - innervation Muscles Neuronal Plasticity Neurons - physiology Neurotransmitter Agents - secretion Neurotransmitters Proteins Quantification Sensors Synapses Synaptic transmission Synaptic Vesicles - physiology Synaptotagmins - deficiency Synaptotagmins - genetics Synaptotagmins - physiology Transgenes
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