pak2a mutations cause cerebral hemorrhage in redhead zebrafish

The zebrafish is a powerful model for studying vascular development, demonstrating remarkable conservation of this process with mammals. Here, we identify a zebrafish mutant, redhead (rhdmi¹⁴⁹), that exhibits embryonic CNS hemorrhage with intact gross development of the vasculature and normal hemost...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-08, Vol.104 (35), p.13996-14001
Hauptverfasser:	Buchner, David A, Su, Fengyun, Yamaoka, Jennifer S, Kamei, Makoto, Shavit, Jordan A, Barthel, Linda K, McGee, Beth, Amigo, Julio D, Kim, Seongcheol, Hanosh, Andrew W, Jagadeeswaran, Pudur, Goldman, Daniel, Lawson, Nathan D, Raymond, Pamela A, Weinstein, Brant M, Ginsburg, David, Lyons, Susan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Biological Sciences Brain Cardiovascular system Cells Cerebral hemorrhage Cerebral Hemorrhage - embryology Cerebral Hemorrhage - genetics Cerebrovascular Circulation - genetics Chromosome Mapping Danio rerio Embryo, Nonmammalian Embryos Endothelial cells Exons Freshwater Genes, Recessive Genetic mutation Genetic Variation Hemorrhage In situ hybridization Kinases Messenger RNA Mutation p21-Activated Kinases Phenotypes Polymorphism, Restriction Fragment Length Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction RNA - genetics Transcription, Genetic Zebrafish Zebrafish - genetics Zebrafish Proteins - genetics
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