Innate response to self-antigen significantly exacerbates burn wound depth

A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that t...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2007-03, Vol.104 (10), p.3973-3977
Hauptverfasser: Suber, Freeman, Carroll, Michael C, Moore, Francis D. Jr
Format: Artikel
Sprache:eng
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Zusammenfassung:A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0609026104