Innate response to self-antigen significantly exacerbates burn wound depth
A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that t...
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Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2007-03, Vol.104 (10), p.3973-3977 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response. |
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ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.0609026104 |