Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL

Networks of transcriptional regulatory proteins dictate specification of neural lineages from multipotent retinal progenitors. Rod photoreceptor differentiation requires the basic motif-leucine zipper (bZIP) transcription factor NRL, because loss of Nrl in mice (Nrl⁻/⁻) results in complete transform...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-01, Vol.104 (5), p.1679-1684
Hauptverfasser:	Oh, Edwin C.T, Khan, Naheed, Novelli, Elena, Khanna, Hemant, Strettoi, Enrica, Swaroop, Anand
Format:	Artikel
Sprache:	eng
Schlagworte:	Amacrine cells Animals Antibodies Basic-Leucine Zipper Transcription Factors - metabolism Basic-Leucine Zipper Transcription Factors - physiology Biological Sciences Cell Differentiation Cell Line Cell Lineage Electroretinography Eye Proteins - metabolism Eye Proteins - physiology Gene expression Gene Expression Regulation Mice Mice, Transgenic Multipotent stem cells Neural stem cells Neuroglia Neurons Neurons - metabolism Neurosciences Photoreceptor Cells, Vertebrate - metabolism Photoreceptors Promoter Regions, Genetic Retina Retina - metabolism Retinal rods Rodents Stem cells Synapses - metabolism Synaptic Transmission
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