Transcriptional regulation of the sodium-coupled neutral amino acid transporter (SNAT2) by 17β-estradiol

The sodium-coupled neutral amino acid transporter 2 (SNAT2) translocates small neutral amino acids into the mammary gland to promote cell proliferation during gestation. It is known that SNAT2 expression increases during pregnancy, and in vitro studies indicate that this transporter is induced by 17...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-08, Vol.111 (31), p.11443-11448
Hauptverfasser:	Velázquez-Villegas, Laura A., Ortíz, Víctor, Ström, Anders, Torres, Nimbe, Engler, David A., Matsunami, Risë, Ordaz-Rosado, David, García-Becerra, Rocío, López-Barradas, Adriana M., Larrea, Fernando, Gustafsson, Jan-Åke, Tovar, Armando R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid transport systems Amino Acid Transport Systems - genetics Amino Acid Transport Systems - metabolism Amino acids Animals Antigens, Nuclear - metabolism Base Sequence Biological Sciences Cell Nucleus - metabolism DNA-Binding Proteins - metabolism Epithelium - metabolism Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogens Female Gene Expression Regulation - drug effects Genes Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism HeLa Cells Hormonal regulation Humans Ku Autoantigen Lactation Mammary glands Mammary Glands, Animal - metabolism Molecular Sequence Data Peptide Fragments - metabolism Poly(ADP-ribose) Polymerases - metabolism Pregnancy Promoter regions Protein Binding - drug effects Protein Binding - genetics Rats Response Elements - genetics Transcription, Genetic - drug effects
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