Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

The relationship between the cells that initiate cancer and the cancer stem-like cells that propagate tumors has been poorly defined. In a human prostate tissue transformation model, basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors. Tumors contain feat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-12, Vol.110 (50), p.20111-20116
Hauptverfasser:	Stoyanova, Tanya, Cooper, Aaron R., Drake, Justin M., Liu, Xian, Armstrong, Andrew J., Pienta, Kenneth J., Zhang, Hong, Kohn, Donald B., Huang, Jiaoti, Witte, Owen N., Goldstein, Andrew S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - physiopathology Basal cell neoplasms beta Catenin - metabolism Biological Sciences Blotting, Western Cancer Cancer therapies Cell Transformation, Neoplastic - metabolism Eukaryotic Initiation Factor-4E - metabolism Flow Cytometry Gene expression Gene Expression Regulation, Neoplastic - physiology Genotype & phenotype Granulocyte macrophage progenitor cells Histology Humans Immunohistochemistry Male neoplasm cells Neoplasms, Basal Cell - physiopathology oncogenes Phenotype Phenotypes Prostate Prostate cancer prostatic neoplasms Prostatic Neoplasms - physiopathology Proteins signal transduction Signal Transduction - physiology squamous cell carcinoma Stem cells Tumors
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