BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease

Bone morphogenetic protein 9 (BMP9) promotes the acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons (BFCN) during development and protects these neurons from cholinergic dedifferentiation following axotomy when administered in vivo. A decline in BFCN function occurs in p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-11, Vol.110 (48), p.19567-19572
Hauptverfasser:	Burke, Rebecca M., Norman, Timothy A., Haydar, Tarik F., Slack, Barbara E., Leeman, Susan E., Blusztajn, Jan Krzysztof, Mellott, Tiffany J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease amyloid amyloidosis Amyloidosis - metabolism Amyloids Analysis of Variance Animal models Animals Biological and medical sciences Biological Sciences bone morphogenetic proteins cerebral cortex choline acetyltransferase Cholinergic Neurons - drug effects Cholinergic Neurons - metabolism Cholinergics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease models Female Forebrain Fundamental and applied biological sciences. Psychology Gene expression genetically modified organisms genotype Genotype & phenotype green fluorescent protein Growth Differentiation Factor 2 - administration & dosage Growth Differentiation Factor 2 - metabolism Growth Differentiation Factor 2 - pharmacology Hippocampus Hippocampus hippocampus Immunoassay Immunoblotting Immunohistochemistry insulin-like growth factor I Insulin-like growth factors Male Medical sciences memory Mice Microscopy, Fluorescence nerve growth factor Neurochemistry Neurology Neurons patients phenotype receptor protein-tyrosine kinase Receptors Rodents Signal transduction Vertebrates: nervous system and sense organs
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