Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse

This study examines the question of whether apolipoprotein E (apoE) alters steady-state concentrations of plasma cholesterol carried in low density lipoproteins (LDL-C) by acting as a competitive inhibitor of hepatic LDL uptake or by altering the rate of net cholesterol delivery from the intestinal...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-12, Vol.92 (26), p.12500-12504
Hauptverfasser:	Woollett, L.A. (University of Texas Southwestern Medical Center, Dallas, TX.), Osono, Y, Herz, J, Dietschy, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	ABSORCION DIGESTIVA ABSORPTION DIGESTIVE Animals Apolipoproteins E - deficiency Apolipoproteins E - genetics Apolipoproteins E - pharmacology Binding, Competitive BIOSINTESIS BIOSYNTHESE Carbon Radioisotopes CHIMIORECEPTEUR CHOLESTEROL Cholesterol - biosynthesis Cholesterol - blood Cholesterol - metabolism Cholesterol, Dietary - metabolism Cholesterol, HDL - metabolism Cholesterol, LDL - metabolism Cholesterol, VLDL - metabolism Cholesterols COLESTEROL Crosses, Genetic Female FOIE HIGADO Humans INHIBICION INHIBITION INTESTIN Intestinal Absorption Intestine, Small - metabolism INTESTINOS Lipids LIPOPROTEINAS LIPOPROTEINE Lipoproteins Lipoproteins, LDL - metabolism Liver Liver - metabolism Male Mathematical constants Metabolism METABOLISME DES PROTEINES METABOLISMO PROTEICO Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Mutant Strains Plasma density PLASMA SANGUIN PLASMA SANGUINEO PROTEINAS PROTEINE Proteins QUIMIORECEPTORES RATON Receptors, LDL - drug effects Receptors, LDL - metabolism Rodents Sitosterols - metabolism SOURIS Sterols
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