A Structural Basis for a Phosphoramide Mustard-Induced DNA Interstrand Cross-Link at 5'-d(GAC)

Phosphoramide mustard-induced DNA interstrand cross-links were studied both in vitro and by computer simulation. The local determinants for the formation of phosphoramide mustard-induced DNA interstrand cross-links were defined by using different pairs of synthetic oligonucleotide duplexes, each of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-12, Vol.92 (26), p.12170-12174
Hauptverfasser:	Dong, Q, Barsky, D, Colvin, M E, Melius, C F, Ludeman, S M, Moravek, J F, Colvin, O M, Bigner, D D, Modrich, P, Friedman, H S
Format:	Artikel
Sprache:	eng
Schlagworte:	Atoms Base Sequence Biochemistry Cancer Computer based modeling Cross-Linking Reagents Deoxyribonucleic acid DNA DNA - chemistry DNA - drug effects Enthalpy Gels Hydrolysis Medical research Models, Molecular Molecular biology Molecular dynamics Molecular Sequence Data Mustards Nitrogen Nucleic Acid Conformation Oligodeoxyribonucleotides - chemistry Oligonucleotides Phosphoramide Mustards - chemistry Phosphoramide Mustards - pharmacology Piperidines Structure-Activity Relationship
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