Glial Cell Line-Derived Neurotrophic Factor but not Transforming Growth Factor β3 Prevents Delayed Degeneration of Nigral Dopaminergic Neurons Following Striatal 6-Hydroxydopamine Lesion

Glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor β3 (TGF-β3) are members of the TGF-β superfamily with high neurotrophic activity on cultured nigral dopamine neurons. We investigated the effects of intracerebral administration of GDNF and TGF-β3 on the delayed cell d...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-09, Vol.92 (19), p.8935-8939
Hauptverfasser:	Sauer, Hansjorg, Rosenblad, Carl, Bjorklund, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell death Lesions Neuroglia Neurons Neuroscience Protective effects Substantia nigra Transforming growth factors Vehicles
Online-Zugang:	Volltext
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