Disruption of the Adenosine Deaminase Gene Causes Hepatocellular Impairment and Perinatal Lethality in Mice

We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally. Their lymphoid tissues were not largely affected. Accumulation of ADA substra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-04, Vol.92 (9), p.3673-3677
Hauptverfasser:	Wakamiya, Maki, Blackburn, Michael R., Jurecic, Roland, McArthur, Mark J., Geske, Robert S., Cartwright, Joiner, Mitani, Kohnosuke, Vaishnav, Sukeshi, Belmont, John W., Kellems, Rodney E., Finegold, Milton J., Montgomery, Charles A., Bradley, Allan, Caskey, C. Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Adenosine Triphosphate - metabolism Aging - physiology Alleles Animals B lymphocytes Biochemistry Deoxyadenine Nucleotides - metabolism Enzymes Female Fetus Genes, Lethal Genetics Genotype Gestational Age Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - enzymology Hematopoietic Stem Cells - pathology Hepatocytes Homeostasis Leukocytes - cytology Leukocytes - enzymology Leukocytes - pathology Liver Liver - embryology Liver - enzymology Liver - pathology Mice Mice, Mutant Strains Molecular biology Mutagenesis Mutation Nucleosides Pregnancy Purines Purines - metabolism Restriction Mapping Rodents T lymphocytes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!