Selective Inhibition of Inducible Cyclooxygenase 2 in vivo is Antiinflammatory and Nonulcerogenic

We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-04, Vol.91 (8), p.3228-3232
Hauptverfasser:	MASFERRER, J. L, ZWEIFEL, B. S, MANNING, P. T, HAUSER, S. D, LEAHY, K. M, SMITH, W. G, ISAKSON, P. C, SEIBERT, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Inflammatory Agents Antiinflammatories Arthritis Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Carrageenan Cyclooxygenase inhibitors Cyclooxygenase Inhibitors - pharmacology Dexamethasone - pharmacology Gastric Mucosa - metabolism Gavage Human resources Indomethacin - pharmacology Inflammation Inflammation - enzymology Isoenzymes - antagonists & inhibitors Lesions Macrophages Male Medical sciences Messenger RNA Mice Molecular Sequence Data Nitrobenzenes - pharmacology Pharmacology Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - physiology Prostaglandins - metabolism Rats Rats, Inbred Lew Rodents Side effects Stomach Sulfonamides - pharmacology
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