Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins

Proteins secreted by the yeast Saccharomyces cerevisiae are usually modified by the addition at asparagine-linked glycosylation sites of large heterogeneous mannan units that are highly immunogenic. Secreted proteins from mnn1 mnn9 mutant strains, in contrast, have homogeneous Man10GlcNAc2 oligosacc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-03, Vol.91 (7), p.2723-2727
Hauptverfasser:	Yip, Carli Lam, Welch, Susan K., Klebl, Franz, Gilbert, Teresa, Seidel, Paul, Grant, Francis J., O'Hara, Patrick J., MacKay, Vivian L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antiserum aparato golgi appareil de golgi Base Sequence Biochemistry Biological and medical sciences Carbohydrate Sequence Cloning, Molecular DNA endoplasmic reticulum Endoplasmic Reticulum - chemistry Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism gene Genes Genes, Fungal - genetics Genes. Genome Genetic mutation glicosiltransferasas Glycosylation glycosyltransferase glycosyltransferases golgi apparatus Golgi Apparatus - chemistry Mannosyltransferases Membrane Glycoproteins - genetics Membrane proteins Molecular and cellular biology Molecular genetics Molecular Sequence Data nucleotide sequence Oligosaccharides Phenotypes Plasmids Protein Processing, Post-Translational proteinas proteine Proteins reticulo endoplasmatico reticulum endoplasmique Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins secrecion secretion secuencia nucleica sequence nucleique Yeast Yeasts
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