Incorporation of Marine Lipids into Mitochondrial Membranes Increases Susceptibility to Damage by Calcium and Reactive Oxygen Species: Evidence for Enhanced Activation of Phospholipase A2in Mitochondria Enriched with n - 3 Fatty Acids

Experiments were designed to evaluate the susceptibility of mitochondrial membranes enriched with n-3 fatty acids to damage by Ca2+and reactive oxygen species. Fatty acid content and respiratory function were assessed in renal cortical mitochondria isolated from fish-oil- and beef-tallow-fed rats. D...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-11, Vol.87 (22), p.8845-8849
Hauptverfasser:	Malis, Charles D., Weber, Peter C., Leaf, Alexander, Bonventre, Joseph V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bleeding time Fatty acids Fish oil Mitochondria Mitochondrial membranes Nonesterified fatty acids Phospholipids Rats Reactive oxygen species Respiration
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!