Conversion of a Helix-Turn-Helix Motif Sequence-Specific DNA Binding Protein into a Site-Specific DNA Cleavage Agent

Escherichia coli catabolite gene activator protein (CAP) is a helix-turn-helix motif sequence-specific DNA binding protein [de Crombrugghe, B., Busby, S. \& Buc, H. (1984) Science 224, 831-838; and Pabo, C. \& Sauer, R. (1984) Annu. Rev. Biochem. 53, 293-321]. In this work, CAP has been conv...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-04, Vol.87 (8), p.2882-2886
Hauptverfasser:	Ebright, Richard H., Ebright, Yon W., Pendergrast, P. Shannon, Gunasekera, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Base Sequence Biochemistry Coliphages - metabolism Cyclic AMP Receptor Protein - metabolism Cysteine Dams DNA DNA binding proteins DNA cleavage DNA, Viral - metabolism DNA-Binding Proteins - metabolism Electrophoresis Escherichia coli Escherichia coli - metabolism Gels Models, Molecular Molecular Sequence Data Molecules Nucleic Acid Conformation Nucleotides Phenanthrolines Protein Conformation Restriction Mapping
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