Labile Disulfide Bonds in Human Placental Insulin Receptor

The disulfide crosslinking pattern of human placental insulin receptor was investigated using selective reduction with tributylphosphine followed by alkylation with N-[3H]ethylmaleimide. Insulin receptor contains a single sulfhydryl group in each β subunit whose alkylation with N-[3H]ethylmaleimide...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-01, Vol.87 (1), p.419-423
Hauptverfasser:	Finn, Frances M., Ridge, Kevin D., Hofmann, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism ALBUMINS ALKALI METAL COMPOUNDS ALKYLATION ANIMALS ATP BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biochemistry Biological and medical sciences CARBON 14 COMPOUNDS CATIONS Cell receptors Cell structures and functions CHARGED PARTICLES Chemical bonding CHEMICAL BONDS CHEMICAL REACTIONS Chlorides CROSS-LINKING DAYS LIVING RADIOISOTOPES Dimers Disulfides Disulfides - analysis ELECTRON CAPTURE RADIOISOTOPES Electrophoresis, Polyacrylamide Gel Ethylmaleimide - pharmacology Female FETAL MEMBRANES Fundamental and applied biological sciences. Psychology Gels GLYCOPROTEINS HALIDES HALOGEN COMPOUNDS HORMONES Humans HYDROGEN COMPOUNDS IMIDES INORGANIC PHOSPHORS INSULIN INTERMEDIATE MASS NUCLEI IODIDES IODINE 125 IODINE COMPOUNDS IODINE ISOTOPES IONS ISOTOPE APPLICATIONS ISOTOPES Kinetics LABELLED COMPOUNDS LIGHT NUCLEI Macromolecular Substances MAMMALS MAN Manganese - pharmacology MANGANESE COMPOUNDS MEMBRANE PROTEINS MEMBRANES Molecular and cellular biology MOLECULAR STRUCTURE NUCLEI NUCLEOTIDES ODD-EVEN NUCLEI ODD-ODD NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Oxidation-Reduction PEPTIDE HORMONES Phosphines - pharmacology PHOSPHORS PHOSPHORUS 32 PHOSPHORUS ISOTOPES PHOSPHORYLATION PLACENTA Placenta - metabolism POLYMERIZATION Pregnancy PRIMATES Protein Conformation Protein-Tyrosine Kinases - metabolism PROTEINS RADIOISOTOPES RADIORECEPTOR ASSAY Receptor, Insulin - isolation & purification Receptor, Insulin - metabolism RECEPTORS REDUCTION SODIUM COMPOUNDS SODIUM IODIDES TRACER TECHNIQUES TRANSITION ELEMENT COMPOUNDS TRITIUM COMPOUNDS VERTEBRATES 550201 > Biochemistry-- Tracer Techniques
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