Specific Cleavage of the p15A Primer Precursor by Ribonuclease H at the Origin of DNA Replication

We report studies on the mechanism of initiation of DNA replication by p15A, a small plasmid whose origin of replication is known to function much as does that of ColE1. Previous work has shown that an RNA primer for DNA synthesis is generated by the action of RNase H (EC 3.1.26.4) on a precursor tr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1982-12, Vol.79 (23), p.7082-7086
Hauptverfasser:	Selzer, Gerald, Tomizawa, Jun-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA DNA Polymerase I - metabolism DNA Replication Enzymes Escherichia coli Gels Hybridity Nucleic Acid Precursors - genetics Nucleotides Oligonucleotides Plasmids Product labeling Ribonucleases - metabolism RNA RNA precursors RNA, Bacterial - genetics Substrate Specificity Transcription, Genetic
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