Toward a New Anti-Inflammatory and Analgesic Agent
In an comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al provide evidence of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception.
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2000-07, Vol.97 (14), p.7676-7677 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7677 |
|---|---|
| container_issue | 14 |
| container_start_page | 7676 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 97 |
| creator | Regoli, Domenico |
| description | In an comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al provide evidence of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception. |
| doi_str_mv | 10.1073/pnas.150233397 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pnas_</sourceid><recordid>TN_cdi_jstor_primary_122981</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>122981</jstor_id><sourcerecordid>122981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486t-48569cbf9ffec4b4eb5fe9827d82ffb4c658f8649642fa761dfd92d01b2a6c143</originalsourceid><addsrcrecordid>eNptkUtLAzEUhYMoWh9bN4IMLnQ1Na_JA9wU8VEQ3eg6ZDJJnTKPmsxY_femtNYqrgK537n33HsAOEZwiCAnl7NGhyHKICaESL4FBghKlDIq4TYYQIh5Kiime2A_hCmEUGYC7oI9BAWTlOIBwM_tXPsi0cmjnSejpivTceMqXde6a_1nopsi_upqYkNpktHENt0h2HG6CvZo9R6Al9ub5-v79OHpbnw9ekgNFaxLqciYNLmTzllDc2rzzFkpMC8Edi6nhmXCieiUUew0Z6hwhcQFRDnWzCBKDsDVsu-sz2tbmDja60rNfFlr_6laXarflaZ8VZP2XREaN43y85Xct2-9DZ2qy2BsVenGtn1QHGFKpViAZ3_Aadv7uHNQGCIiMoJYhIZLyPg2BG_d2geCapGEWiSh1klEwemm-w18efoIXKyAhfC7LLlCVHHGmXJ9VXX2o9to9T8ZgZMlMA0xtJ9RGEuByBfCsaU5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201385316</pqid></control><display><type>article</type><title>Toward a New Anti-Inflammatory and Analgesic Agent</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Regoli, Domenico</creator><creatorcontrib>Regoli, Domenico</creatorcontrib><description>In an comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al provide evidence of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.150233397</identifier><identifier>PMID: 10869442</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Analgesics ; Animal migration behavior ; Animals ; Anti-Inflammatory Agents ; Bradykinin Receptor Antagonists ; Capsaicin - pharmacology ; Commentaries ; Cyclooxygenase 2 ; Formaldehyde - pharmacology ; Inflammation ; Inflammation - etiology ; Interleukin-1 - metabolism ; Interleukins ; Isoenzymes - metabolism ; Kinins ; Ligands ; Medical research ; Mice ; Mice, Knockout ; Neurons ; Neutrophils ; Pain - etiology ; Pathology ; Prostaglandin-Endoperoxide Synthases - metabolism ; Receptor, Bradykinin B1 ; Receptors ; Receptors, Bradykinin - genetics ; Receptors, Bradykinin - metabolism ; Receptors, Neurokinin-1 - metabolism ; Rodents ; Shock, Septic - etiology ; Up regulation</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (14), p.7676-7677</ispartof><rights>Copyright 1993-2000 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Jul 5, 2000</rights><rights>Copyright © The National Academy of Sciences 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-48569cbf9ffec4b4eb5fe9827d82ffb4c658f8649642fa761dfd92d01b2a6c143</citedby><cites>FETCH-LOGICAL-c486t-48569cbf9ffec4b4eb5fe9827d82ffb4c658f8649642fa761dfd92d01b2a6c143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/97/14.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/122981$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/122981$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10869442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regoli, Domenico</creatorcontrib><title>Toward a New Anti-Inflammatory and Analgesic Agent</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>In an comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al provide evidence of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception.</description><subject>Analgesics</subject><subject>Animal migration behavior</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents</subject><subject>Bradykinin Receptor Antagonists</subject><subject>Capsaicin - pharmacology</subject><subject>Commentaries</subject><subject>Cyclooxygenase 2</subject><subject>Formaldehyde - pharmacology</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukins</subject><subject>Isoenzymes - metabolism</subject><subject>Kinins</subject><subject>Ligands</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Neurons</subject><subject>Neutrophils</subject><subject>Pain - etiology</subject><subject>Pathology</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Receptor, Bradykinin B1</subject><subject>Receptors</subject><subject>Receptors, Bradykinin - genetics</subject><subject>Receptors, Bradykinin - metabolism</subject><subject>Receptors, Neurokinin-1 - metabolism</subject><subject>Rodents</subject><subject>Shock, Septic - etiology</subject><subject>Up regulation</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtLAzEUhYMoWh9bN4IMLnQ1Na_JA9wU8VEQ3eg6ZDJJnTKPmsxY_femtNYqrgK537n33HsAOEZwiCAnl7NGhyHKICaESL4FBghKlDIq4TYYQIh5Kiime2A_hCmEUGYC7oI9BAWTlOIBwM_tXPsi0cmjnSejpivTceMqXde6a_1nopsi_upqYkNpktHENt0h2HG6CvZo9R6Al9ub5-v79OHpbnw9ekgNFaxLqciYNLmTzllDc2rzzFkpMC8Edi6nhmXCieiUUew0Z6hwhcQFRDnWzCBKDsDVsu-sz2tbmDja60rNfFlr_6laXarflaZ8VZP2XREaN43y85Xct2-9DZ2qy2BsVenGtn1QHGFKpViAZ3_Aadv7uHNQGCIiMoJYhIZLyPg2BG_d2geCapGEWiSh1klEwemm-w18efoIXKyAhfC7LLlCVHHGmXJ9VXX2o9to9T8ZgZMlMA0xtJ9RGEuByBfCsaU5</recordid><startdate>20000705</startdate><enddate>20000705</enddate><creator>Regoli, Domenico</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000705</creationdate><title>Toward a New Anti-Inflammatory and Analgesic Agent</title><author>Regoli, Domenico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-48569cbf9ffec4b4eb5fe9827d82ffb4c658f8649642fa761dfd92d01b2a6c143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analgesics</topic><topic>Animal migration behavior</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents</topic><topic>Bradykinin Receptor Antagonists</topic><topic>Capsaicin - pharmacology</topic><topic>Commentaries</topic><topic>Cyclooxygenase 2</topic><topic>Formaldehyde - pharmacology</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukins</topic><topic>Isoenzymes - metabolism</topic><topic>Kinins</topic><topic>Ligands</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Neurons</topic><topic>Neutrophils</topic><topic>Pain - etiology</topic><topic>Pathology</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Receptor, Bradykinin B1</topic><topic>Receptors</topic><topic>Receptors, Bradykinin - genetics</topic><topic>Receptors, Bradykinin - metabolism</topic><topic>Receptors, Neurokinin-1 - metabolism</topic><topic>Rodents</topic><topic>Shock, Septic - etiology</topic><topic>Up regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regoli, Domenico</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regoli, Domenico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toward a New Anti-Inflammatory and Analgesic Agent</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2000-07-05</date><risdate>2000</risdate><volume>97</volume><issue>14</issue><spage>7676</spage><epage>7677</epage><pages>7676-7677</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>In an comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al provide evidence of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>10869442</pmid><doi>10.1073/pnas.150233397</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (14), p.7676-7677 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_jstor_primary_122981 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Analgesics Animal migration behavior Animals Anti-Inflammatory Agents Bradykinin Receptor Antagonists Capsaicin - pharmacology Commentaries Cyclooxygenase 2 Formaldehyde - pharmacology Inflammation Inflammation - etiology Interleukin-1 - metabolism Interleukins Isoenzymes - metabolism Kinins Ligands Medical research Mice Mice, Knockout Neurons Neutrophils Pain - etiology Pathology Prostaglandin-Endoperoxide Synthases - metabolism Receptor, Bradykinin B1 Receptors Receptors, Bradykinin - genetics Receptors, Bradykinin - metabolism Receptors, Neurokinin-1 - metabolism Rodents Shock, Septic - etiology Up regulation |
| title | Toward a New Anti-Inflammatory and Analgesic Agent |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A20%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pnas_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toward%20a%20New%20Anti-Inflammatory%20and%20Analgesic%20Agent&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Regoli,%20Domenico&rft.date=2000-07-05&rft.volume=97&rft.issue=14&rft.spage=7676&rft.epage=7677&rft.pages=7676-7677&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.150233397&rft_dat=%3Cjstor_pnas_%3E122981%3C/jstor_pnas_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201385316&rft_id=info:pmid/10869442&rft_jstor_id=122981&rfr_iscdi=true |