3-Methyladenine: Specific Inhibitor of Autophagic/Lysosomal Protein Degradation in Isolated Rat Hepatocytes

3-Methyladenine (5 mM) inhibits endogenous protein degradation in isolated rat hepatocytes by about 60%, while having no adverse effect on the degradation of an exogenous protein (asialofetuin), on protein synthesis, or on intracellular ATP levels. 3-Methyladenine appears to act specifically upon th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1982-03, Vol.79 (6), p.1889-1892
Hauptverfasser:	Seglen, Per O., Gordon, Paul B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenosine Triphosphate - metabolism Amino acids Amino Acids - metabolism Animals Autolysis - physiopathology Biological Sciences: Cell Biology Cells Cells, Cultured Dose response relationship Hepatocytes Liver - cytology Liver - metabolism Lysosomes Lysosomes - drug effects Percentages Phagocytosis - drug effects Propylamines Protein Biosynthesis - drug effects Protein synthesis Proteins - metabolism Purines Rats
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