Rings, bracelet or snaps: fashionable alternatives for Smc complexes
The mechanism of higher order chromosome organization has eluded researchers for over 100 years. A breakthrough occurred with the discovery of multi-subunit protein complexes that contain a core of two molecules from the structural maintenance of chromosome (Smc) family. Smc complexes are important...
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| Veröffentlicht in: | Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2005-03, Vol.360 (1455), p.537-542 |
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| container_title | Philosophical transactions of the Royal Society of London. Series B. Biological sciences |
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| creator | Huang, Catherine E Milutinovich, Mark Koshland, Douglas |
| description | The mechanism of higher order chromosome organization has eluded researchers for over 100 years. A breakthrough occurred with the discovery of multi-subunit protein complexes that contain a core of two molecules from the structural maintenance of chromosome (Smc) family. Smc complexes are important structural components of chromosome organization in diverse aspects of DNA metabolism, including sister chromatid cohesion, condensation, global gene repression, DNA repair and homologous recombination. In these different processes, Smc complexes may facilitate chromosome organization by tethering together two parts of the same or different chromatin strands. The mechanism of tethering by Smc complexes remains to be elucidated, but a number of intriguing topological alternatives are suggested by the unusual structural features of Smc complexes, including their large coiled-coil domains and ATPase activities. Distinguishing between these possibilities will require innovative new approaches. |
| doi_str_mv | 10.1098/rstb.2004.1609 |
| format | Article |
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A breakthrough occurred with the discovery of multi-subunit protein complexes that contain a core of two molecules from the structural maintenance of chromosome (Smc) family. Smc complexes are important structural components of chromosome organization in diverse aspects of DNA metabolism, including sister chromatid cohesion, condensation, global gene repression, DNA repair and homologous recombination. In these different processes, Smc complexes may facilitate chromosome organization by tethering together two parts of the same or different chromatin strands. The mechanism of tethering by Smc complexes remains to be elucidated, but a number of intriguing topological alternatives are suggested by the unusual structural features of Smc complexes, including their large coiled-coil domains and ATPase activities. 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Series B. Biological sciences</title><addtitle>Philos Trans R Soc Lond B Biol Sci</addtitle><description>The mechanism of higher order chromosome organization has eluded researchers for over 100 years. A breakthrough occurred with the discovery of multi-subunit protein complexes that contain a core of two molecules from the structural maintenance of chromosome (Smc) family. Smc complexes are important structural components of chromosome organization in diverse aspects of DNA metabolism, including sister chromatid cohesion, condensation, global gene repression, DNA repair and homologous recombination. In these different processes, Smc complexes may facilitate chromosome organization by tethering together two parts of the same or different chromatin strands. The mechanism of tethering by Smc complexes remains to be elucidated, but a number of intriguing topological alternatives are suggested by the unusual structural features of Smc complexes, including their large coiled-coil domains and ATPase activities. Distinguishing between these possibilities will require innovative new approaches.</description><subject>Adenosine triphosphatases</subject><subject>Adenosine Triphosphatases - metabolism</subject><subject>Adenosine Triphosphatases - physiology</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial Proteins - physiology</subject><subject>Bracelets</subject><subject>Cell Cycle - physiology</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Cycle Proteins - physiology</subject><subject>Chromatids</subject><subject>Chromatids - metabolism</subject><subject>Chromatids - physiology</subject><subject>Chromosomal Proteins, Non-Histone</subject><subject>Chromosomes</subject><subject>Cohesins</subject><subject>Cohesion</subject><subject>Condensation</subject><subject>DNA</subject><subject>DNA repair</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Eukaryotic Cells - physiology</subject><subject>Fungal Proteins</subject><subject>Models, Biological</subject><subject>Molecules</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Multiprotein Complexes - physiology</subject><subject>Nuclear Proteins - metabolism</subject><subject>Nuclear Proteins - physiology</subject><subject>Proteins</subject><subject>Sister Chromatid Cohesion</subject><subject>Structural Maintenance Of Chromosomes</subject><issn>0962-8436</issn><issn>1471-2970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2P0zAQxSMEYkvhyg2UEydSPLEdxxxAUD6KVAnUXeBoOYndupvGwU7Klr8et6kKFWIvsaL5vZl5z46ix4AmgHj-wvmumKQIkQlkiN-JRkAYJCln6G40QjxLk5zg7CJ64P0aIcQpI_ejC6A5Z8D4KHq3MM3SP48LJ0tVqy62LvaNbP3LWEu_MraRRa1iWXfKNbIzW-VjHZjLTRmXdtPW6kb5h9E9LWuvHh3PcfT1w_ur6SyZf_74afpmnpSM0i4hildAZVEAYF5VmiMApVNZKV0SjXMtKcmLjFBdQQWQpjgtaao15JpWwAGPo1dD37YvNqoqVdM5WYvWmY10O2GlEeeVxqzE0m4F0IwTRkODZ8cGzv7ole_Exvjgu5aNsr0XGcsxScNnHE0GsHTWe6f0aQggsQ9e7IMX--DFPvggePr3an_wY9IBuB4AZ3chI1sa1e3E2vYh1tqLxeXV2y3OkAFCqUA5BsQIBy5-mXaYFYrCeN8rcUDO5_-7Dr5t2n9NPBlUa99Zd_KAAwDpwUMy1I3v1M2pLt11SA4zKr7lRMzY9MsCfZ-JeeDRwK_McvXTOCXO1gk_7dHYwRLFLEhe3yrZL1zapgsXfCYUuq_DS6g0_g0HMPYz</recordid><startdate>20050329</startdate><enddate>20050329</enddate><creator>Huang, Catherine E</creator><creator>Milutinovich, Mark</creator><creator>Koshland, Douglas</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050329</creationdate><title>Rings, bracelet or snaps: fashionable alternatives for Smc complexes</title><author>Huang, Catherine E ; 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| subjects | Adenosine triphosphatases Adenosine Triphosphatases - metabolism Adenosine Triphosphatases - physiology Bacterial Proteins - metabolism Bacterial Proteins - physiology Bracelets Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Chromatids Chromatids - metabolism Chromatids - physiology Chromosomal Proteins, Non-Histone Chromosomes Cohesins Cohesion Condensation DNA DNA repair DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Eukaryotic Cells - physiology Fungal Proteins Models, Biological Molecules Multiprotein Complexes - metabolism Multiprotein Complexes - physiology Nuclear Proteins - metabolism Nuclear Proteins - physiology Proteins Sister Chromatid Cohesion Structural Maintenance Of Chromosomes |
| title | Rings, bracelet or snaps: fashionable alternatives for Smc complexes |
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