Aspects of gene expression and its control - Drosophila chorion gene amplification: a model system for the study of chromosome replication

Aspects of gene expression and its control - Drosophila chorion gene amplification: a model system for the study of chromosome replication

Two chromosomal domains of 80-100 kilobases containing Drosophila chorion genes undergo tissue-specific amplification in ovarian follicle cells during oogenesis. We have investigated the ability of small segments of DNA from within these regions to induce amplification after insertion into new chrom...

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Veröffentlicht in:Philosophical transactions of the Royal Society of London. Series B, Biological sciences Biological sciences, 1984-12, Vol.307 (1132), p.239-245
Hauptverfasser: DeCicco, Diane V., Wakimoto, Barbara, Kalfayan, Laura, Levine, J., Spradling, A. C.
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container_title Philosophical transactions of the Royal Society of London. Series B, Biological sciences
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creator DeCicco, Diane V.
Wakimoto, Barbara
Kalfayan, Laura
Levine, J.
Spradling, A. C.
description Two chromosomal domains of 80-100 kilobases containing Drosophila chorion genes undergo tissue-specific amplification in ovarian follicle cells during oogenesis. We have investigated the ability of small segments of DNA from within these regions to induce amplification after insertion into new chromosomal sites by P element-mediated transformation. Certain transduced chorion DNA sequences initiated a pattern of tissue-specific differential replication that was identical to norm al chorion amplification. Both the transformed chorion DNA as well as flanking rosy DNA sequences underw ent amplification. O ur results suggest that differential chorion DNA replication is mediated by specific origin-containing sequences located near the centre of the amplified domains. The possible role of such sequences in normal programmes of replication is discussed.
doi_str_mv 10.1098/rstb.1984.0124
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title Aspects of gene expression and its control - Drosophila chorion gene amplification: a model system for the study of chromosome replication
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