Asymmetry of the Rat Acetylcholine Receptor Subunits in the Narrow Region of the Pore

The acetylcholine receptor (AChR) channel is a pentameric protein in which every subunit contributes to the conducting parts of the pore. Recent studies of rat nicotinic AChR channels mutated in the α-subunit revealed that a threonine residue (αT264) in the transmembrane segment M2 forms part of the...

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Veröffentlicht in:	Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1992-09, Vol.249 (1326), p.317-324
Hauptverfasser:	Villarroel, A., Herlitze, S., Witzemann, V., Koenen, M., Sakmann, Bert
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Amino Acids - chemistry Animals Cholinergic receptors Cloning, Molecular Electric Conductivity Electric current Hydroxylation Hydroxyls Ion channels Ion Channels - chemistry Ion Channels - genetics Molecular Sequence Data Mutagenesis, Site-Directed Nicotinic receptors Oocytes Point mutation Protein Conformation Rats Receptors Receptors, Cholinergic - chemistry Receptors, Cholinergic - genetics RNA
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