1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one:  A Selective High-Affinity Antagonist for the Human Dopamine D4 Receptor with Excellent Selectivity over Ion Channels

After the requirement of pseudocycle formation in the ureas 3 and 7 for hD4 binding and selectivity was confirmed, structural hybridization with the known hD4 ligand 2 led to the design and identification of the lead 4-(2-oxo-1,3-dihydroimidazol-2-yl)piperidine 8. Optimization studies were carried o...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1999-07, Vol.42 (14), p.2706-2715
Hauptverfasser:	Carling, Robert W, Moore, Kevin W, Moyes, Christopher R, Jones, Elizabeth A, Bonner, Katrine, Emms, Frances, Marwood, Rosemary, Patel, Shil, Patel, Smita, Fletcher, Alan E, Beer, Margaret, Sohal, Bindi, Pike, Andrew, Leeson, Paul D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!