Structure of the Metal−Water Complex in Ras·GDP Studied by High-Field EPR Spectroscopy and 31P NMR Spectroscopy

The small GTPase Ras plays a key role as a molecular switch in the intercellular signal transduction. On Mg2+ → Mn2+ substituted samples, the first ligand sphere of the metal ion in the inactive, GDP-bound Ras has been studied by continuous wave EPR at 94 GHz (W-band). Via replacement of normal wate...

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Veröffentlicht in:	Biochemistry (Easton) 2001-02, Vol.40 (7), p.1884-1889
Hauptverfasser:	Rohrer, Martin, Prisner, Thomas F, Brügmann, Oliver, Käss, Hanno, Spoerner, Michael, Wittinghofer, Alfred, Kalbitzer, Hans Robert
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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