Novel Acid Labile COL1 Trityl-Linked Difluoronucleoside Immunoconjugates:  Synthesis, Characterization, and Biological Activity1

LY207702 (1) is a difluorinated purine nucleoside that exhibits impressive antitumor activity in preclinical models. This agent, however, also possesses cardiotoxicity which limits the potential clinical utility of this novel drug candidate. We therefore developed linker chemistry whereby regioselec...

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Veröffentlicht in:	Bioconjugate chemistry 1996-07, Vol.7 (4), p.497-510
Hauptverfasser:	Patel, Vinod F, Hardin, Julie N, Mastro, John M, Law, Kevin L, Zimmermann, John L, Ehlhardt, William J, Woodland, Joseph M, Starling, James J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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