Inhibition of Phospholipase C-δ1 Catalytic Activity by Sphingomyelin

We measured the ability of sphingomyelin (SPM) to inhibit phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] hydrolysis catalyzed by human phospholipase C-δ1 (PLC-δ1) in model membranes and detergent phospholipid mixed micelles. SPM strongly inhibited PLC-δ1 catalytic activity measured in large unila...

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Veröffentlicht in:	Biochemistry (Easton) 1996-11, Vol.35 (47), p.14882-14888
Hauptverfasser:	Scarlata, Suzanne, Gupta, Rakesh, Garcia, Pilar, Keach, Heather, Shah, Shefali, Kasireddy, Chandraprakash Reddy, Bittman, Robert, Rebecchi, Mario J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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