Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides1

The modified triester approach has been further improved and refined to the synthesis of defined sequences of deoxyribooligonucleotides. Improvements include arylsulfonyltetrazoles as faster and milder condensing agents, benzenesulfonic acid to avoid depurination during deblocking of trityl protecti...

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Veröffentlicht in:Nucleic acids research 1977-02, Vol.4 (2), p.353-371
Hauptverfasser: Stawinski, J., Hozumi, T., Narang, S.A, Bahl, C.P., Wu, R.
Format: Artikel
Sprache:eng ; jpn
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