The Intrachain Disulfide Bond of β2-Microglobulin Is Not Essential for the Immunoglobulin Fold at Neutral pH, but Is Essential for Amyloid Fibril Formation at Acidic pH

β2-Microglobulin (β2M), the light chain of the type I major histocompatibility complex, is a major component of dialysis-related amyloid fibrils. β2M in the native state has a typical immunoglobulin fold with a buried intrachain disulfide bond. The conformation and stability of recombinant β2M in wh...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2002-01, Vol.131 (1), p.45-52
Hauptverfasser:	Ohhashi, Yumiko, Hagihara, Yoshihisa, Kozhukh, Gennady, Hoshino, Masaru, Hasegawa, Kazuhiro, Yamaguchi, Itaru, Naiki, Hironobu, Goto, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	amyloid conformational-disease disulfide β2-microglobulin
Online-Zugang:	Volltext
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