Molecular dynamics of the 5-HT1a receptor and ligands

A 3-D model of the human 5-HT1a receptor was constructed from its amino acid sequence by computer graphics techniques, molecular mechanics calculations and molecular dynamics simulations. The model has seven α-helical membrane spanning segments, which form a central core containing a putative ligand...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 1993-09, Vol.6 (7), p.691-700
Hauptverfasser:	Sylte, Ingebrigt, Edvardsen, Øyvind, Dahl, Svein G.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT1a recepto ipsapirone methiothepin molecular dynamics receptor modeling serotonin
Online-Zugang:	Volltext
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