Preclinical Toxicology Studies with Nizatidine, A New H2-Receptor Antagonist: Acute, Subchronic, and Chronic Toxicity Evaluations

Nizatidine (NIZ), a new antiulcer drug, was evaluated for toxicity in acute, subchronic, and chronic tests. Acute toxicity studies were conducted in rats, mice, dogs, and monkeys. Median lethal doses (MLD) in rodents were greater than 1600,230, and 1000 mg/kg by oral (po), iv, and sc administration,...

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Veröffentlicht in:Toxicological sciences 1989-11, Vol.13 (4), p.778-792
Hauptverfasser: PROBST, KAREN S., HIGDON, GARY L., FISHER, LAWRENCE F., MCGRATH, JOHN P., ADAMS, ELIZABETH R., EMMERSON, JOHN L.
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Sprache:eng
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