Abnormal accumulation of copper in LEC rat liver induces expression of p53 and nuclear matrix-bound p21waf 1/cip 1

The LEC rat is an inbred mutant strain which spontaneously develops liver injury and subsequent liver cancer. Liver injury in LEC rats has recently been shown to be closely related to abnormal copper accumulation in the liver. Previously, we reported that LEC rat hepatocytes lose their growth potent...

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Veröffentlicht in:	Carcinogenesis (New York) 1996-10, Vol.17 (10), p.2157-2161
Hauptverfasser:	Obata, Hiroyuki, Sawada, Norimasa, Isomura, Hiroshi, Mori, Michio
Format:	Artikel
Sprache:	eng ; jpn
Online-Zugang:	Volltext
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