Molecular Cloning of the Human β1,4 N-Acetylgalactosaminyltransferase Responsible for the Biosynthesis of the Sda Histo-Blood Group Antigen: The Sequence Predicts a Very Long Cytoplasmic Domain

The Sda antigen is a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. This epitope, whose structure is Siaα2,3[GalNAcβ1,4]Gal β1,4GlcNAc, is synthesized by a β1,4 N-acetylgalactosaminyltransferase (β4GalNAc-T) that transfers a β1,4-linked GalNAc to the galact...

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