Direct optimization of dose–volume histogram metrics in radiation therapy treatment planning

We present a method of directly optimizing on deviations in clinical goal values in radiation therapy treatment planning. Using a new mathematical framework in which metrics derived from the dose–volume histogram are regarded as functionals of an auxiliary random variable, we are able to obtain volu...

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Veröffentlicht in:	Biomedical physics & engineering express 2020-11, Vol.6 (6), p.65018
Hauptverfasser:	Zhang, Tianfang, Bokrantz, Rasmus, Olsson, Jimmy
Format:	Artikel
Sprache:	eng
Schlagworte:	clinical goals dose-volume histogram inverse planning mean-tail-dose objective functions smooth approximation
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