Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration
Barrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this stud...
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| Veröffentlicht in: | Biomedical materials (Bristol) 2018-03, Vol.13 (3), p.035009-035009 |
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| creator | Saska, Sybele Pigossi, Suzane C Oliveira, Guilherme J P L Teixeira, Lucas N Capela, Marisa V Gonçalves, Andreia de Oliveira, Paulo T Messaddeq, Younès Ribeiro, Sidney J L Gaspar, Ana Maria Minarelli Marchetto, Reinaldo |
| description | Barrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with osteogenic growth peptide (OGP(10-14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological study was performed to evaluate the BC-COL OGP(10-14) membranes on bone healing after GBR in noncritical defects in rat femur. The results showed that the BC-COL and BC-COL OGP(10-14) membranes promoted cell proliferation and alkaline phosphatase activity in osteoblastic cell cultures. However, ECM mineralization was similar between cultures grown on BC OGP(10-14) and BC-COL OGP(10-14) membranes. In vivo results showed that all the membranes tested, including the peptide-free BC membrane, promoted better bone regeneration than control group. Furthermore, the BC-COL OGP(10-14) membranes induced higher radiographic density in the repaired bone than the other groups at 1, 4 and 16 weeks. Histomorphometric analyses revealed that the BC-COL OGP(10-14) induced higher percentage of bone tissue in the repaired area at 2 and 4 weeks than others membranes. In general, these biopolymer-based membranes might be potential candidates for bone regeneration applications. |
| doi_str_mv | 10.1088/1748-605X/aaaa2d |
| format | Article |
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Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with osteogenic growth peptide (OGP(10-14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological study was performed to evaluate the BC-COL OGP(10-14) membranes on bone healing after GBR in noncritical defects in rat femur. The results showed that the BC-COL and BC-COL OGP(10-14) membranes promoted cell proliferation and alkaline phosphatase activity in osteoblastic cell cultures. However, ECM mineralization was similar between cultures grown on BC OGP(10-14) and BC-COL OGP(10-14) membranes. In vivo results showed that all the membranes tested, including the peptide-free BC membrane, promoted better bone regeneration than control group. Furthermore, the BC-COL OGP(10-14) membranes induced higher radiographic density in the repaired bone than the other groups at 1, 4 and 16 weeks. Histomorphometric analyses revealed that the BC-COL OGP(10-14) induced higher percentage of bone tissue in the repaired area at 2 and 4 weeks than others membranes. In general, these biopolymer-based membranes might be potential candidates for bone regeneration applications.</description><identifier>ISSN: 1748-605X</identifier><identifier>EISSN: 1748-605X</identifier><identifier>DOI: 10.1088/1748-605X/aaaa2d</identifier><identifier>PMID: 29363620</identifier><identifier>CODEN: BMBUCS</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>Animals ; Animals, Newborn ; bacterial cellulose ; barrier membrane ; Biopolymers - chemistry ; Bone and Bones - pathology ; Bone Regeneration ; Cell Culture Techniques ; Cell Membrane - metabolism ; Cell Proliferation ; collagen ; Collagen - chemistry ; Histones - chemistry ; Intercellular Signaling Peptides and Proteins - chemistry ; Male ; Osteoblasts - cytology ; Osteogenesis - drug effects ; Peptides - chemistry ; Polymers - chemistry ; Rats ; Rats, Wistar</subject><ispartof>Biomedical materials (Bristol), 2018-03, Vol.13 (3), p.035009-035009</ispartof><rights>2018 IOP Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-2c2052eac053de693a75fa8f926413093d45fd215f792287477fe16ed3defffb3</citedby><cites>FETCH-LOGICAL-c447t-2c2052eac053de693a75fa8f926413093d45fd215f792287477fe16ed3defffb3</cites><orcidid>0000-0001-7067-6119</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1748-605X/aaaa2d/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,776,780,27901,27902,53821,53868</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29363620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saska, Sybele</creatorcontrib><creatorcontrib>Pigossi, Suzane C</creatorcontrib><creatorcontrib>Oliveira, Guilherme J P L</creatorcontrib><creatorcontrib>Teixeira, Lucas N</creatorcontrib><creatorcontrib>Capela, Marisa V</creatorcontrib><creatorcontrib>Gonçalves, Andreia</creatorcontrib><creatorcontrib>de Oliveira, Paulo T</creatorcontrib><creatorcontrib>Messaddeq, Younès</creatorcontrib><creatorcontrib>Ribeiro, Sidney J L</creatorcontrib><creatorcontrib>Gaspar, Ana Maria Minarelli</creatorcontrib><creatorcontrib>Marchetto, Reinaldo</creatorcontrib><title>Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration</title><title>Biomedical materials (Bristol)</title><addtitle>BMM</addtitle><addtitle>Biomed. Mater</addtitle><description>Barrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with osteogenic growth peptide (OGP(10-14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological study was performed to evaluate the BC-COL OGP(10-14) membranes on bone healing after GBR in noncritical defects in rat femur. The results showed that the BC-COL and BC-COL OGP(10-14) membranes promoted cell proliferation and alkaline phosphatase activity in osteoblastic cell cultures. However, ECM mineralization was similar between cultures grown on BC OGP(10-14) and BC-COL OGP(10-14) membranes. In vivo results showed that all the membranes tested, including the peptide-free BC membrane, promoted better bone regeneration than control group. Furthermore, the BC-COL OGP(10-14) membranes induced higher radiographic density in the repaired bone than the other groups at 1, 4 and 16 weeks. Histomorphometric analyses revealed that the BC-COL OGP(10-14) induced higher percentage of bone tissue in the repaired area at 2 and 4 weeks than others membranes. In general, these biopolymer-based membranes might be potential candidates for bone regeneration applications.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>bacterial cellulose</subject><subject>barrier membrane</subject><subject>Biopolymers - chemistry</subject><subject>Bone and Bones - pathology</subject><subject>Bone Regeneration</subject><subject>Cell Culture Techniques</subject><subject>Cell Membrane - metabolism</subject><subject>Cell Proliferation</subject><subject>collagen</subject><subject>Collagen - chemistry</subject><subject>Histones - chemistry</subject><subject>Intercellular Signaling Peptides and Proteins - chemistry</subject><subject>Male</subject><subject>Osteoblasts - cytology</subject><subject>Osteogenesis - drug effects</subject><subject>Peptides - chemistry</subject><subject>Polymers - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1748-605X</issn><issn>1748-605X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMouq7ePUlverA6SZq2OeriFyx4UfAW0mayVrZNTVqW_fdmWRUPmkuGl2dmmIeQEwqXFMryihZZmeYgXq90fMzskMlPtPurPiCHIbwDCCm43CcHTPKc5wwmRN80rnfLdYs-rXRAk7TYVl53GBIdgqsbPcRw1QxviQsDugV2TZ0svFvFpMd-aAwm1vlkMcbKJJXrMPEYMfR6aFx3RPasXgY8_vqn5OXu9nn2kM6f7h9n1_O0zrJiSFnNQDDUNQhuMJdcF8Lq0kqWZ5SD5CYT1jAqbCEZK4usKCzSHE2krbUVn5Lz7dzeu48Rw6DaJtS4XMZb3BgUlRJKkQODiMIWrb0LwaNVvW9a7deKgtqIVRtzamNObcXGltOv6WPVovlp-DYZgbMtEH2qdzf6Lh6rqrZVlCuugAsAqXpjI3nxB_nv5k95D5JC</recordid><startdate>20180314</startdate><enddate>20180314</enddate><creator>Saska, Sybele</creator><creator>Pigossi, Suzane C</creator><creator>Oliveira, Guilherme J P L</creator><creator>Teixeira, Lucas N</creator><creator>Capela, Marisa V</creator><creator>Gonçalves, Andreia</creator><creator>de Oliveira, Paulo T</creator><creator>Messaddeq, Younès</creator><creator>Ribeiro, Sidney J L</creator><creator>Gaspar, Ana Maria Minarelli</creator><creator>Marchetto, Reinaldo</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7067-6119</orcidid></search><sort><creationdate>20180314</creationdate><title>Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration</title><author>Saska, Sybele ; Pigossi, Suzane C ; Oliveira, Guilherme J P L ; Teixeira, Lucas N ; Capela, Marisa V ; Gonçalves, Andreia ; de Oliveira, Paulo T ; Messaddeq, Younès ; Ribeiro, Sidney J L ; Gaspar, Ana Maria Minarelli ; Marchetto, Reinaldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-2c2052eac053de693a75fa8f926413093d45fd215f792287477fe16ed3defffb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>bacterial cellulose</topic><topic>barrier membrane</topic><topic>Biopolymers - chemistry</topic><topic>Bone and Bones - pathology</topic><topic>Bone Regeneration</topic><topic>Cell Culture Techniques</topic><topic>Cell Membrane - metabolism</topic><topic>Cell Proliferation</topic><topic>collagen</topic><topic>Collagen - chemistry</topic><topic>Histones - chemistry</topic><topic>Intercellular Signaling Peptides and Proteins - chemistry</topic><topic>Male</topic><topic>Osteoblasts - cytology</topic><topic>Osteogenesis - drug effects</topic><topic>Peptides - chemistry</topic><topic>Polymers - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saska, Sybele</creatorcontrib><creatorcontrib>Pigossi, Suzane C</creatorcontrib><creatorcontrib>Oliveira, Guilherme J P L</creatorcontrib><creatorcontrib>Teixeira, Lucas N</creatorcontrib><creatorcontrib>Capela, Marisa V</creatorcontrib><creatorcontrib>Gonçalves, Andreia</creatorcontrib><creatorcontrib>de Oliveira, Paulo T</creatorcontrib><creatorcontrib>Messaddeq, Younès</creatorcontrib><creatorcontrib>Ribeiro, Sidney J L</creatorcontrib><creatorcontrib>Gaspar, Ana Maria Minarelli</creatorcontrib><creatorcontrib>Marchetto, Reinaldo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical materials (Bristol)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saska, Sybele</au><au>Pigossi, Suzane C</au><au>Oliveira, Guilherme J P L</au><au>Teixeira, Lucas N</au><au>Capela, Marisa V</au><au>Gonçalves, Andreia</au><au>de Oliveira, Paulo T</au><au>Messaddeq, Younès</au><au>Ribeiro, Sidney J L</au><au>Gaspar, Ana Maria Minarelli</au><au>Marchetto, Reinaldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration</atitle><jtitle>Biomedical materials (Bristol)</jtitle><stitle>BMM</stitle><addtitle>Biomed. Mater</addtitle><date>2018-03-14</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>035009</spage><epage>035009</epage><pages>035009-035009</pages><issn>1748-605X</issn><eissn>1748-605X</eissn><coden>BMBUCS</coden><abstract>Barrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with osteogenic growth peptide (OGP(10-14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological study was performed to evaluate the BC-COL OGP(10-14) membranes on bone healing after GBR in noncritical defects in rat femur. The results showed that the BC-COL and BC-COL OGP(10-14) membranes promoted cell proliferation and alkaline phosphatase activity in osteoblastic cell cultures. However, ECM mineralization was similar between cultures grown on BC OGP(10-14) and BC-COL OGP(10-14) membranes. In vivo results showed that all the membranes tested, including the peptide-free BC membrane, promoted better bone regeneration than control group. Furthermore, the BC-COL OGP(10-14) membranes induced higher radiographic density in the repaired bone than the other groups at 1, 4 and 16 weeks. Histomorphometric analyses revealed that the BC-COL OGP(10-14) induced higher percentage of bone tissue in the repaired area at 2 and 4 weeks than others membranes. In general, these biopolymer-based membranes might be potential candidates for bone regeneration applications.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>29363620</pmid><doi>10.1088/1748-605X/aaaa2d</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-7067-6119</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Animals, Newborn bacterial cellulose barrier membrane Biopolymers - chemistry Bone and Bones - pathology Bone Regeneration Cell Culture Techniques Cell Membrane - metabolism Cell Proliferation collagen Collagen - chemistry Histones - chemistry Intercellular Signaling Peptides and Proteins - chemistry Male Osteoblasts - cytology Osteogenesis - drug effects Peptides - chemistry Polymers - chemistry Rats Rats, Wistar |
| title | Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration |
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