Antifungal Activity of the Essential oil of Thymus vulgaris L. and Thymol on Experimentally Induced Dermatomycoses

The in vivo evaluation of the toxicological and antifungal activity of the essential oil of Thymus vulgaris L. and its main component thymol was made on 2-month-old male Wistar rats. We examined the therapeutic potency against experimentally induced dermatomycoses in rats, using the most frequent de...

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Veröffentlicht in:	Drug development and industrial pharmacy 2008-01, Vol.34 (12), p.1388-1393
Hauptverfasser:	Sokovi, M., Glamo lija, J., iri, A., Kataranovski, D., Marin, P. D., Vukojevi, J., Brki, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antifungal activity Antifungal Agents - pharmacology Biological and medical sciences dermatomycetes dermatomycoses Dermatomycoses - drug therapy General pharmacology Male Medical sciences Oils, Volatile - pharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Wistar thymol Thymol - pharmacology Thymus Plant - chemistry Thymus vulgaris Trichophyton spp
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Beschreibung
Zusammenfassung:	The in vivo evaluation of the toxicological and antifungal activity of the essential oil of Thymus vulgaris L. and its main component thymol was made on 2-month-old male Wistar rats. We examined the therapeutic potency against experimentally induced dermatomycoses in rats, using the most frequent dermatomycetes, Trichophyton mentagrophytes, T. rubrum, and T. tonsurans. The therapeutic efficacy of a 1% solution of the essential oil of Thymus vulgaris and thymol as well as the commercial preparation bifonazole was evaluated. During the 37-day observation period the oil-treated animals were cured.
ISSN:	0363-9045 1520-5762
DOI:	10.1080/03639040802130053