Experimental Assessment of the Protective Activity of Diazepam on the Acute Toxicity of Chloroquine
Abstract The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD 50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected intraperitoneally to male and female rats at dose levels of 2.5, 7.5, 20,...
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| Veröffentlicht in: | Clinical toxicology (Philadelphia, Pa.) Pa.), 1983-01, Vol.20 (3), p.271-279 |
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| container_title | Clinical toxicology (Philadelphia, Pa.) |
| container_volume | 20 |
| creator | Crouzette, J. Vicaut, E. Palombo, S. Girre, C. Fournier, P. E. |
| description | Abstract
The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD 50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected intraperitoneally to male and female rats at dose levels of 2.5, 7.5, 20, 55, and 148 mg/kg. An untreated group served as control. A significant decrease of the mortality rate was observed at the dose levels 7.5, 20, and 55 mg/kg with optimal effect at 20 mg/kg. This mortality rate was analysed by analysis of variance. The occurrence of two types of symptoms: convulsions and respiratory disturbances was analysed by the chi square method. |
| doi_str_mv | 10.3109/15563658308990070 |
| format | Article |
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The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD 50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected intraperitoneally to male and female rats at dose levels of 2.5, 7.5, 20, 55, and 148 mg/kg. An untreated group served as control. A significant decrease of the mortality rate was observed at the dose levels 7.5, 20, and 55 mg/kg with optimal effect at 20 mg/kg. This mortality rate was analysed by analysis of variance. The occurrence of two types of symptoms: convulsions and respiratory disturbances was analysed by the chi square method.</description><identifier>ISSN: 1556-3650</identifier><identifier>ISSN: 0731-3810</identifier><identifier>EISSN: 1556-9519</identifier><identifier>EISSN: 1097-9875</identifier><identifier>DOI: 10.3109/15563658308990070</identifier><identifier>PMID: 6620441</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Chloroquine - toxicity ; Diazepam - therapeutic use ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug toxicity and drugs side effects treatment ; Female ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains</subject><ispartof>Clinical toxicology (Philadelphia, Pa.), 1983-01, Vol.20 (3), p.271-279</ispartof><rights>1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-74ffc62c63a6cf0f2dbb42b50bef2f71522584b9c28466ac41d49369d7bb3d9b3</citedby><cites>FETCH-LOGICAL-c430t-74ffc62c63a6cf0f2dbb42b50bef2f71522584b9c28466ac41d49369d7bb3d9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/15563658308990070$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/15563658308990070$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,59624,59730,60413,60519,61198,61233,61379,61414</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9373862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6620441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crouzette, J.</creatorcontrib><creatorcontrib>Vicaut, E.</creatorcontrib><creatorcontrib>Palombo, S.</creatorcontrib><creatorcontrib>Girre, C.</creatorcontrib><creatorcontrib>Fournier, P. E.</creatorcontrib><title>Experimental Assessment of the Protective Activity of Diazepam on the Acute Toxicity of Chloroquine</title><title>Clinical toxicology (Philadelphia, Pa.)</title><addtitle>J Toxicol Clin Toxicol</addtitle><description>Abstract
The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD 50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected intraperitoneally to male and female rats at dose levels of 2.5, 7.5, 20, 55, and 148 mg/kg. An untreated group served as control. A significant decrease of the mortality rate was observed at the dose levels 7.5, 20, and 55 mg/kg with optimal effect at 20 mg/kg. This mortality rate was analysed by analysis of variance. The occurrence of two types of symptoms: convulsions and respiratory disturbances was analysed by the chi square method.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chloroquine - toxicity</subject><subject>Diazepam - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>1556-3650</issn><issn>0731-3810</issn><issn>1556-9519</issn><issn>1097-9875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EKqXwASyQsmBb8CtOLNhEpTykSrAo68h2bDVVGgfbhZavJ6EBCSF1NTO-5448F4BzBK8IgvwaxTEjLE4JTDmHMIEHYNi9jXmM-GHftwA8BifeLyEkKeVoAAaMYUgpGgI13TTalStdB1FFmffa-26IrInCQkcvzgatQvmuo6wrZdh20l0pPnUjVpGtv7FMrYOO5nZTqp6YLCrr7Nu6rPUpODKi8vqsryPwej-dTx7Hs-eHp0k2GytKYBgn1BjFsGJEMGWgwYWUFMsYSm2wSVCMcZxSyRVOKWNCUVRQThgvEilJwSUZAbTbq5z13mmTN-1lwm1zBPMur_xfXq3nYudp1nKli19HH1CrX_a68EpUxolalf4X4yQhKcMtdrvDytpYtxIf1lVFHsS2DeHHQ_b94uaPfaFFFRZKOJ0v7drVbWp7bvgCLOWY8Q</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Crouzette, J.</creator><creator>Vicaut, E.</creator><creator>Palombo, S.</creator><creator>Girre, C.</creator><creator>Fournier, P. E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19830101</creationdate><title>Experimental Assessment of the Protective Activity of Diazepam on the Acute Toxicity of Chloroquine</title><author>Crouzette, J. ; Vicaut, E. ; Palombo, S. ; Girre, C. ; Fournier, P. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-74ffc62c63a6cf0f2dbb42b50bef2f71522584b9c28466ac41d49369d7bb3d9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chloroquine - toxicity</topic><topic>Diazepam - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crouzette, J.</creatorcontrib><creatorcontrib>Vicaut, E.</creatorcontrib><creatorcontrib>Palombo, S.</creatorcontrib><creatorcontrib>Girre, C.</creatorcontrib><creatorcontrib>Fournier, P. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crouzette, J.</au><au>Vicaut, E.</au><au>Palombo, S.</au><au>Girre, C.</au><au>Fournier, P. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Assessment of the Protective Activity of Diazepam on the Acute Toxicity of Chloroquine</atitle><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle><addtitle>J Toxicol Clin Toxicol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>20</volume><issue>3</issue><spage>271</spage><epage>279</epage><pages>271-279</pages><issn>1556-3650</issn><issn>0731-3810</issn><eissn>1556-9519</eissn><eissn>1097-9875</eissn><abstract>Abstract
The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD 50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected intraperitoneally to male and female rats at dose levels of 2.5, 7.5, 20, 55, and 148 mg/kg. An untreated group served as control. A significant decrease of the mortality rate was observed at the dose levels 7.5, 20, and 55 mg/kg with optimal effect at 20 mg/kg. This mortality rate was analysed by analysis of variance. The occurrence of two types of symptoms: convulsions and respiratory disturbances was analysed by the chi square method.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>6620441</pmid><doi>10.3109/15563658308990070</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1556-3650 |
| ispartof | Clinical toxicology (Philadelphia, Pa.), 1983-01, Vol.20 (3), p.271-279 |
| issn | 1556-3650 0731-3810 1556-9519 1097-9875 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_15563658308990070 |
| source | MEDLINE; Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | Analysis of Variance Animals Biological and medical sciences Chloroquine - toxicity Diazepam - therapeutic use Dose-Response Relationship, Drug Drug Interactions Drug toxicity and drugs side effects treatment Female Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Rats Rats, Inbred Strains |
| title | Experimental Assessment of the Protective Activity of Diazepam on the Acute Toxicity of Chloroquine |
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