Airway Responsiveness to Indirect Challenges in COPD
ABSTRACT Patients with chronic obstructive pulmonary disease (COPD) demonstrate airway hyperresponsiveness to a number of indirect stimuli. Hyperresponsiveness to cold air hyperventilation, exercise, and drugs like propranalol and methoxamine seem to be able to distinguish patients with COPD from th...
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| Veröffentlicht in: | Chronic obstructive pulmonary disease 2010-04, Vol.7 (2), p.133-140 |
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| container_title | Chronic obstructive pulmonary disease |
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| creator | Hassan, Nesreen M. Hargreave, Frederick E. Nair, Parameswaran |
| description | ABSTRACT
Patients with chronic obstructive pulmonary disease (COPD) demonstrate airway hyperresponsiveness to a number of indirect stimuli. Hyperresponsiveness to cold air hyperventilation, exercise, and drugs like propranalol and methoxamine seem to be able to distinguish patients with COPD from those with asthma, whereas hyperresponsiveness to stimuli like adenosine 5-monophosphate (AMP) and hypertonic saline seem unable to do so. The relationship of airway responsiveness to indirect stimuli and airway inflammation has received little study. The clinical relevance of hyperresponsiveness to an indirect challenge, including the impact on the natural history, relation to types of bronchitis, baseline airway calibre, and response to treatment need to be studied. |
| doi_str_mv | 10.3109/15412551003631741 |
| format | Article |
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Patients with chronic obstructive pulmonary disease (COPD) demonstrate airway hyperresponsiveness to a number of indirect stimuli. Hyperresponsiveness to cold air hyperventilation, exercise, and drugs like propranalol and methoxamine seem to be able to distinguish patients with COPD from those with asthma, whereas hyperresponsiveness to stimuli like adenosine 5-monophosphate (AMP) and hypertonic saline seem unable to do so. The relationship of airway responsiveness to indirect stimuli and airway inflammation has received little study. The clinical relevance of hyperresponsiveness to an indirect challenge, including the impact on the natural history, relation to types of bronchitis, baseline airway calibre, and response to treatment need to be studied.</description><identifier>ISSN: 1541-2555</identifier><identifier>EISSN: 1541-2563</identifier><identifier>DOI: 10.3109/15412551003631741</identifier><identifier>PMID: 20397814</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>Airway hyperresponsiveness ; Asthma - diagnosis ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Hyperreactivity - physiopathology ; Bronchial Provocation Tests ; Chronic obstructive pulmonary disease, asthma ; COPD ; Forced Expiratory Volume ; Humans ; Indirect challenge ; Medical sciences ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Respiratory Function Tests</subject><ispartof>Chronic obstructive pulmonary disease, 2010-04, Vol.7 (2), p.133-140</ispartof><rights>Copyright © 2010 Informa Healthcare USA, Inc. 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-aeb2ba327767f232c1f47627a568e8fb59c95138a7d844c58e6c223cc3e8fe6c3</citedby><cites>FETCH-LOGICAL-c478t-aeb2ba327767f232c1f47627a568e8fb59c95138a7d844c58e6c223cc3e8fe6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22695697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20397814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassan, Nesreen M.</creatorcontrib><creatorcontrib>Hargreave, Frederick E.</creatorcontrib><creatorcontrib>Nair, Parameswaran</creatorcontrib><title>Airway Responsiveness to Indirect Challenges in COPD</title><title>Chronic obstructive pulmonary disease</title><addtitle>COPD</addtitle><description>ABSTRACT
Patients with chronic obstructive pulmonary disease (COPD) demonstrate airway hyperresponsiveness to a number of indirect stimuli. Hyperresponsiveness to cold air hyperventilation, exercise, and drugs like propranalol and methoxamine seem to be able to distinguish patients with COPD from those with asthma, whereas hyperresponsiveness to stimuli like adenosine 5-monophosphate (AMP) and hypertonic saline seem unable to do so. The relationship of airway responsiveness to indirect stimuli and airway inflammation has received little study. 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Patients with chronic obstructive pulmonary disease (COPD) demonstrate airway hyperresponsiveness to a number of indirect stimuli. Hyperresponsiveness to cold air hyperventilation, exercise, and drugs like propranalol and methoxamine seem to be able to distinguish patients with COPD from those with asthma, whereas hyperresponsiveness to stimuli like adenosine 5-monophosphate (AMP) and hypertonic saline seem unable to do so. The relationship of airway responsiveness to indirect stimuli and airway inflammation has received little study. The clinical relevance of hyperresponsiveness to an indirect challenge, including the impact on the natural history, relation to types of bronchitis, baseline airway calibre, and response to treatment need to be studied.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>20397814</pmid><doi>10.3109/15412551003631741</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chronic obstructive pulmonary disease, 2010-04, Vol.7 (2), p.133-140 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Airway hyperresponsiveness Asthma - diagnosis Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - physiopathology Bronchial Provocation Tests Chronic obstructive pulmonary disease, asthma COPD Forced Expiratory Volume Humans Indirect challenge Medical sciences Pneumology Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - therapy Respiratory Function Tests |
| title | Airway Responsiveness to Indirect Challenges in COPD |
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