Brain oedema and blood-brain barrier permeability in pulsatile and nonpulsatile cardiopulmonary bypass
In pigs subjected to pulsatile or nonpulsatile cardiopulmonary bypass (CPB) at normothermia for 3 hours, evaluation was made of water content in brain tissue (specific gravity measurements), blood-brain permeability to serum proteins (immunocytochemical demonstration of extravasated proteins, using...
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| Veröffentlicht in: | Scandinavian cardiovascular journal : SCJ 1986, Vol.20 (2), p.161-166 |
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| container_title | Scandinavian cardiovascular journal : SCJ |
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| creator | Laursen, Henning Bødker, Anders Andersen, Kurt Waaben, Jens Husum, Bent |
| description | In pigs subjected to pulsatile or nonpulsatile cardiopulmonary bypass (CPB) at normothermia for 3 hours, evaluation was made of water content in brain tissue (specific gravity measurements), blood-brain permeability to serum proteins (immunocytochemical demonstration of extravasated proteins, using perioxidase-antiperoxidase technique) and histopathology (paraffin sections). The specific gravity in parietal cortex was higher after pulsatile than after nonpulsatile CPB or in control pigs, the change corresponding to a 6.3% water increase. The tissue water content was unchanged in the internal capsule, basal ganglia and nucleus accumbens after CPB. The vascular permeability to serum proteins was unchanged after nonpulsatile CPB, but after pulsatile CPB minute foci of extravasated serum proteins appeared. All the animals showed dark neurons in cortical and subcortical regions, but these could have been artefacts in immersion-fixed tissue. There were no other signs of ischaemic tissue damage. The study indicated that cortical oedema may follow pulsatile CPB, the cause being altered permeability of the blood-brain barrier to serum proteins. |
| doi_str_mv | 10.3109/14017438609106495 |
| format | Article |
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The specific gravity in parietal cortex was higher after pulsatile than after nonpulsatile CPB or in control pigs, the change corresponding to a 6.3% water increase. The tissue water content was unchanged in the internal capsule, basal ganglia and nucleus accumbens after CPB. The vascular permeability to serum proteins was unchanged after nonpulsatile CPB, but after pulsatile CPB minute foci of extravasated serum proteins appeared. All the animals showed dark neurons in cortical and subcortical regions, but these could have been artefacts in immersion-fixed tissue. There were no other signs of ischaemic tissue damage. The study indicated that cortical oedema may follow pulsatile CPB, the cause being altered permeability of the blood-brain barrier to serum proteins.</description><identifier>ISSN: 1401-7431</identifier><identifier>ISSN: 0036-5580</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.3109/14017438609106495</identifier><identifier>PMID: 3738447</identifier><identifier>CODEN: SJTCAO</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Blood-Brain Barrier ; Brain - pathology ; Brain Edema - etiology ; Cardiopulmonary Bypass - adverse effects ; Cardiopulmonary Bypass - methods ; Medical sciences ; Specific Gravity ; Swine ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><ispartof>Scandinavian cardiovascular journal : SCJ, 1986, Vol.20 (2), p.161-166</ispartof><rights>1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1986</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-e8418db4b630d8125be636024ed3559917a8a4ab654d859687213b0e5d7aae743</citedby><cites>FETCH-LOGICAL-c345t-e8418db4b630d8125be636024ed3559917a8a4ab654d859687213b0e5d7aae743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/14017438609106495$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/14017438609106495$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4021,27921,27922,27923,61219,61400</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8737044$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3738447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laursen, Henning</creatorcontrib><creatorcontrib>Bødker, Anders</creatorcontrib><creatorcontrib>Andersen, Kurt</creatorcontrib><creatorcontrib>Waaben, Jens</creatorcontrib><creatorcontrib>Husum, Bent</creatorcontrib><title>Brain oedema and blood-brain barrier permeability in pulsatile and nonpulsatile cardiopulmonary bypass</title><title>Scandinavian cardiovascular journal : SCJ</title><addtitle>Scand J Thorac Cardiovasc Surg</addtitle><description>In pigs subjected to pulsatile or nonpulsatile cardiopulmonary bypass (CPB) at normothermia for 3 hours, evaluation was made of water content in brain tissue (specific gravity measurements), blood-brain permeability to serum proteins (immunocytochemical demonstration of extravasated proteins, using perioxidase-antiperoxidase technique) and histopathology (paraffin sections). The specific gravity in parietal cortex was higher after pulsatile than after nonpulsatile CPB or in control pigs, the change corresponding to a 6.3% water increase. The tissue water content was unchanged in the internal capsule, basal ganglia and nucleus accumbens after CPB. The vascular permeability to serum proteins was unchanged after nonpulsatile CPB, but after pulsatile CPB minute foci of extravasated serum proteins appeared. All the animals showed dark neurons in cortical and subcortical regions, but these could have been artefacts in immersion-fixed tissue. There were no other signs of ischaemic tissue damage. The study indicated that cortical oedema may follow pulsatile CPB, the cause being altered permeability of the blood-brain barrier to serum proteins.</description><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Brain - pathology</subject><subject>Brain Edema - etiology</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Cardiopulmonary Bypass - methods</subject><subject>Medical sciences</subject><subject>Specific Gravity</subject><subject>Swine</subject><subject>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><issn>1401-7431</issn><issn>0036-5580</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UE1rFTEUDaK0tfUHuCjMQtyNJi-fg91osVUouLHr4WZyh6Zkkmkyg7x_b9r3bJFCV7k5H5dzDyHvGf3EGe0-M0GZFtwo2jGqRCdfkSOmJGs3lKrXda58WwXskLwt5ZZSJo1kB-SAa26E0Edk_JbBxyahwwkaiK6xISXX2gfYQs4eczNjnhCsD37ZNhWf11Bg8QEfHDHFJ2CA7Hyq_ylFyNvGbmco5YS8GSEUfLd_j8n1xfff5z_aq1-XP8-_XrUDF3Jp0QhmnBVWceoM20iLiiu6Eei4lF3HNBgQYJUUzshOGb1h3FKUTgNgPfSYfNztnXO6W7Es_eTLgCFAxLSWXqtOK0l5FbKdcMiplIxjP2c_1cA9o_19t_2zbqvndL98tRO6R8e-zMp_2PNQBghjhjj48igzmmsq7jOe7WQ-jilP8Cfl4PoFtiHlfx7-Uoov_9lvEMJyU2vH_jatOdZ6X7jhL8bhpxA</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Laursen, Henning</creator><creator>Bødker, Anders</creator><creator>Andersen, Kurt</creator><creator>Waaben, Jens</creator><creator>Husum, Bent</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Almqvist & Wiksell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Brain oedema and blood-brain barrier permeability in pulsatile and nonpulsatile cardiopulmonary bypass</title><author>Laursen, Henning ; Bødker, Anders ; Andersen, Kurt ; Waaben, Jens ; Husum, Bent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-e8418db4b630d8125be636024ed3559917a8a4ab654d859687213b0e5d7aae743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier</topic><topic>Brain - pathology</topic><topic>Brain Edema - etiology</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Cardiopulmonary Bypass - methods</topic><topic>Medical sciences</topic><topic>Specific Gravity</topic><topic>Swine</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laursen, Henning</creatorcontrib><creatorcontrib>Bødker, Anders</creatorcontrib><creatorcontrib>Andersen, Kurt</creatorcontrib><creatorcontrib>Waaben, Jens</creatorcontrib><creatorcontrib>Husum, Bent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laursen, Henning</au><au>Bødker, Anders</au><au>Andersen, Kurt</au><au>Waaben, Jens</au><au>Husum, Bent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain oedema and blood-brain barrier permeability in pulsatile and nonpulsatile cardiopulmonary bypass</atitle><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle><addtitle>Scand J Thorac Cardiovasc Surg</addtitle><date>1986</date><risdate>1986</risdate><volume>20</volume><issue>2</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>1401-7431</issn><issn>0036-5580</issn><eissn>1651-2006</eissn><coden>SJTCAO</coden><abstract>In pigs subjected to pulsatile or nonpulsatile cardiopulmonary bypass (CPB) at normothermia for 3 hours, evaluation was made of water content in brain tissue (specific gravity measurements), blood-brain permeability to serum proteins (immunocytochemical demonstration of extravasated proteins, using perioxidase-antiperoxidase technique) and histopathology (paraffin sections). The specific gravity in parietal cortex was higher after pulsatile than after nonpulsatile CPB or in control pigs, the change corresponding to a 6.3% water increase. The tissue water content was unchanged in the internal capsule, basal ganglia and nucleus accumbens after CPB. The vascular permeability to serum proteins was unchanged after nonpulsatile CPB, but after pulsatile CPB minute foci of extravasated serum proteins appeared. All the animals showed dark neurons in cortical and subcortical regions, but these could have been artefacts in immersion-fixed tissue. There were no other signs of ischaemic tissue damage. The study indicated that cortical oedema may follow pulsatile CPB, the cause being altered permeability of the blood-brain barrier to serum proteins.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>3738447</pmid><doi>10.3109/14017438609106495</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1401-7431 |
| ispartof | Scandinavian cardiovascular journal : SCJ, 1986, Vol.20 (2), p.161-166 |
| issn | 1401-7431 0036-5580 1651-2006 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_14017438609106495 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood-Brain Barrier Brain - pathology Brain Edema - etiology Cardiopulmonary Bypass - adverse effects Cardiopulmonary Bypass - methods Medical sciences Specific Gravity Swine Thoracic and cardiovascular surgery. Cardiopulmonary bypass |
| title | Brain oedema and blood-brain barrier permeability in pulsatile and nonpulsatile cardiopulmonary bypass |
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