Glycosylation of immunoglobulin light chains associated with amyloidosis

AL amyloidosis is a fatal disease caused by deposition of immunoglobulin light chains in a fibrillar form (AL) in various organs. By searching the Kabat database of immunoglobulin sequences using the KabatMan software, we have shown that there is a preponderance of the consensus glycosylation sequon...

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Veröffentlicht in:	Amyloid 2000, Vol.7 (4), p.227-244
Hauptverfasser:	Omtvedt, Lone A., Bailey, David, Renouf, David V., Davies, Michael J., Paramonov, Nikolay A., Haavik, Svein, Husby, Gunnar, Sletten, Knut, Hounsell, Elizabeth F.
Format:	Artikel
Sprache:	eng
Schlagworte:	AL-amyloidosis Amino Acid Sequence amyloid fibrils Amyloidosis - metabolism bisected GlcNAc Glycosylation Humans immunoglobulin Immunoglobulin Light Chains - chemistry light chain Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data protein glycosylation Protein Structure, Secondary
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