Differential Sensitivity to Morphine in Spontaneously Hypertensive and Normotensive Wistar-Kyoto and Wistar Rats

In spontaneously hypertensive rats (SHR) a diminished responsiveness for nociceptive stimuli is present, which might be associated with alterations in endogenous opioid peptide and receptor systems. In SHR, normotensive Wistar-Kyoto controls (WKY) and in Wistar rats the effects of acute morphine adm...

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Veröffentlicht in:	Clinical and experimental hypertension (1993) 1987, Vol.A9 (7), p.1159-1171
Hauptverfasser:	Sitsen, J. M. A., Nijkamp, F. P., de Jong, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals body temperature Body Temperature - drug effects Brain - metabolism H-naloxone binding Hypertension - physiopathology In Vitro Techniques Male morphine Morphine - metabolism Morphine - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Naloxone - metabolism nociception Pain - physiopathology Pain Measurement Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY Sensory Thresholds - drug effects Species Specificity spontaneously hypertensive rat
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