The Effects of Captopril on Blood Pressure in Essential Hypertensive Patients with Low or Normal Plasma Renin Activity. Interference with Autonomic Nervous System

Captopril was administrated to 12 essential hypertensive patients with low or normal plasma renin activity in order to evaluate its effectiveness in decreasing blood pressure and to determine whether the inhibition of converting enzyme could interfere with sympathetic neural activity. Captopril, at...

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Veröffentlicht in:Clinical and experimental hypertension 1981, Vol.3 (3), p.439-454
Hauptverfasser: Esposti, E. Degli, Chiarini, C., Masi, A., Santoro, A., Sturani, A., Umile, A., Zuccalà, A., Zucchelli, P.
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container_end_page 454
container_issue 3
container_start_page 439
container_title Clinical and experimental hypertension
container_volume 3
creator Esposti, E. Degli
Chiarini, C.
Masi, A.
Santoro, A.
Sturani, A.
Umile, A.
Zuccalà, A.
Zucchelli, P.
description Captopril was administrated to 12 essential hypertensive patients with low or normal plasma renin activity in order to evaluate its effectiveness in decreasing blood pressure and to determine whether the inhibition of converting enzyme could interfere with sympathetic neural activity. Captopril, at the doses of 150-450 mg/die, normalized blood pressure in 5 patients (responders) and had no effect on 7 patients (non responders). A significant decrease in heart rate was observed in all patients. Captopril failed to significantly increase plasma renin activity in all patients. Supine plasma levels of catecholamines were significantly higher in responders compared with non responders and decreased significantly after treatment with captopril. The physiological study we performed on all patients suggests an overall integrity of the baroreceptor reflex arc and vascular reactivity to stress before as well as after treatment with captopril. On the contrary, the bradycardia induced by diving test was significantly greater after treatment than before therapy. These findings suggest that the antihypertensive effect of converting enzyme inhibition may be partly due to interference with sympathetic neural activity. Moreover captopril seems to exert an important effect on parasympathetic activity irrespective of blood pressure changes.
doi_str_mv 10.3109/10641968109033675
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Interference with Autonomic Nervous System</title><source>MEDLINE</source><source>Access via Taylor &amp; Francis</source><creator>Esposti, E. Degli ; Chiarini, C. ; Masi, A. ; Santoro, A. ; Sturani, A. ; Umile, A. ; Zuccalà, A. ; Zucchelli, P.</creator><creatorcontrib>Esposti, E. Degli ; Chiarini, C. ; Masi, A. ; Santoro, A. ; Sturani, A. ; Umile, A. ; Zuccalà, A. ; Zucchelli, P.</creatorcontrib><description>Captopril was administrated to 12 essential hypertensive patients with low or normal plasma renin activity in order to evaluate its effectiveness in decreasing blood pressure and to determine whether the inhibition of converting enzyme could interfere with sympathetic neural activity. Captopril, at the doses of 150-450 mg/die, normalized blood pressure in 5 patients (responders) and had no effect on 7 patients (non responders). A significant decrease in heart rate was observed in all patients. Captopril failed to significantly increase plasma renin activity in all patients. Supine plasma levels of catecholamines were significantly higher in responders compared with non responders and decreased significantly after treatment with captopril. The physiological study we performed on all patients suggests an overall integrity of the baroreceptor reflex arc and vascular reactivity to stress before as well as after treatment with captopril. On the contrary, the bradycardia induced by diving test was significantly greater after treatment than before therapy. These findings suggest that the antihypertensive effect of converting enzyme inhibition may be partly due to interference with sympathetic neural activity. 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Degli</au><au>Chiarini, C.</au><au>Masi, A.</au><au>Santoro, A.</au><au>Sturani, A.</au><au>Umile, A.</au><au>Zuccalà, A.</au><au>Zucchelli, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Captopril on Blood Pressure in Essential Hypertensive Patients with Low or Normal Plasma Renin Activity. Interference with Autonomic Nervous System</atitle><jtitle>Clinical and experimental hypertension</jtitle><addtitle>Clin Exp Hypertens</addtitle><date>1981</date><risdate>1981</risdate><volume>3</volume><issue>3</issue><spage>439</spage><epage>454</epage><pages>439-454</pages><issn>1064-1963</issn><issn>0148-3927</issn><eissn>1525-6006</eissn><abstract>Captopril was administrated to 12 essential hypertensive patients with low or normal plasma renin activity in order to evaluate its effectiveness in decreasing blood pressure and to determine whether the inhibition of converting enzyme could interfere with sympathetic neural activity. Captopril, at the doses of 150-450 mg/die, normalized blood pressure in 5 patients (responders) and had no effect on 7 patients (non responders). A significant decrease in heart rate was observed in all patients. Captopril failed to significantly increase plasma renin activity in all patients. Supine plasma levels of catecholamines were significantly higher in responders compared with non responders and decreased significantly after treatment with captopril. The physiological study we performed on all patients suggests an overall integrity of the baroreceptor reflex arc and vascular reactivity to stress before as well as after treatment with captopril. On the contrary, the bradycardia induced by diving test was significantly greater after treatment than before therapy. These findings suggest that the antihypertensive effect of converting enzyme inhibition may be partly due to interference with sympathetic neural activity. 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identifier ISSN: 1064-1963
ispartof Clinical and experimental hypertension, 1981, Vol.3 (3), p.439-454
issn 1064-1963
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recordid cdi_informahealthcare_journals_10_3109_10641968109033675
source MEDLINE; Access via Taylor & Francis
subjects Adult
Autonomic Nervous System - physiopathology
Blood Pressure - drug effects
Captopril - therapeutic use
Epinephrine - blood
Female
Heart Rate - drug effects
Humans
Hypertension - drug therapy
Male
Middle Aged
Norepinephrine - blood
Proline - analogs & derivatives
Renin - blood
Sympathetic Nervous System - drug effects
title The Effects of Captopril on Blood Pressure in Essential Hypertensive Patients with Low or Normal Plasma Renin Activity. Interference with Autonomic Nervous System
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