Microdialysis Assessment of 5-Fluorouracil Release from Thermosensitive Magnetoliposomes Induced by an Electromagnetic Field in Tumor-Bearing Mice
Abstract The current study was designed to evaluate the properties of thermosensitive magnetoliposomes (TMs), a new drug carrier proposed by the authors, in an electromagnetic field pertaining to their selective heating and drug release under an in vivo condition. TMs containing 5-fluorouracil (5-FU...
Gespeichert in:
| Veröffentlicht in: | Journal of drug targeting 1998, Vol.5 (5), p.379-390 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 390 |
|---|---|
| container_issue | 5 |
| container_start_page | 379 |
| container_title | Journal of drug targeting |
| container_volume | 5 |
| creator | Viroonchatapan, Ekapop Sato, Hitoshi Ueno, Masaharu Adachi, Isao Murata, Jun Saiki, Ikuo Tazawa, Kenji Horikoshi, Isamu |
| description | Abstract
The current study was designed to evaluate the properties of thermosensitive magnetoliposomes (TMs), a new drug carrier proposed by the authors, in an electromagnetic field pertaining to their selective heating and drug release under an in vivo condition. TMs containing 5-fluorouracil (5-FU) were prepared by reverse-phase evaporation, injected into the tumor mass of B16-BL6 melanoma in mice, and selectively heated by a 500-kHz electromagnetic field. The release profile of 5-FU from TMs was examined by using a microdialysis technique. The temperature of TMs in the tumor was effectively elevated to 42°C and maintained at this temperature, overcoming the "cooling effect" of blood flow and surrounding tissues. The release kinetics of 5-FU from TMs was successfully analyzed by physiological modeling, which allows the prediction of intratumor drug concentrations during electromagnetic field exposure under various conditions. In conclusion, this study first demonstrated an in vivo evidence for the electromagnetic field-induced thermosensitive release of a drug from TMs in a tumor with the use of microdialysis. |
| doi_str_mv | 10.3109/10611869808997865 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_informahealthcare_journals_10_3109_10611869808997865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17116485</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-80d56e2fe8116366cd2586a3feae4c31b7c0f41fe56ea8206c731f12198631f53</originalsourceid><addsrcrecordid>eNp9kVFrFDEUhQdRaq3-AB-EPIhvU3MnM5kM-tKWbi20CLKCb0M2c9NNySRr7oyyf8NfbNZdCyL0KRfudw435xTFa-CnAnj3HrgEULJTXHVdq2TzpDgGXnVlJQR_upsllBn49rx4QXTPOQgJ_Kg46toWJHTHxa9bZ1IcnPZbcsTOiJBoxDCxaFlTLvwcU5yTNs6zL-hREzKb4siWa0xjJAzkJvcD2a2-CzhF7zaR4ojErsMwGxzYast0YJcezZR1fyhn2MKhH5gLbDmPMZXnqJMLdyxfgy-LZ1Z7wleH96T4urhcXnwqbz5fXV-c3ZSmljCVig-NxMqiApBCSjNUjZJaWNRYGwGr1nBbg8VMaVVxaVoBFirolMxDI06Kd3vfTYrfZ6SpHx0Z9F4HjDP10GbjWu1A2IM5KaKEtt8kN-q07YH3ux76_3rImjcH83k14vCgOASf928Pe01Ge5t0MI4esKqGnXHGPu4xF2xMo_4Zkx_6SW99TH814rErPvwjX6P209rohP19bjXkeB_5w2-0krei</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17116485</pqid></control><display><type>article</type><title>Microdialysis Assessment of 5-Fluorouracil Release from Thermosensitive Magnetoliposomes Induced by an Electromagnetic Field in Tumor-Bearing Mice</title><source>Taylor & Francis:Master (3349 titles)</source><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><creator>Viroonchatapan, Ekapop ; Sato, Hitoshi ; Ueno, Masaharu ; Adachi, Isao ; Murata, Jun ; Saiki, Ikuo ; Tazawa, Kenji ; Horikoshi, Isamu</creator><creatorcontrib>Viroonchatapan, Ekapop ; Sato, Hitoshi ; Ueno, Masaharu ; Adachi, Isao ; Murata, Jun ; Saiki, Ikuo ; Tazawa, Kenji ; Horikoshi, Isamu</creatorcontrib><description>Abstract
The current study was designed to evaluate the properties of thermosensitive magnetoliposomes (TMs), a new drug carrier proposed by the authors, in an electromagnetic field pertaining to their selective heating and drug release under an in vivo condition. TMs containing 5-fluorouracil (5-FU) were prepared by reverse-phase evaporation, injected into the tumor mass of B16-BL6 melanoma in mice, and selectively heated by a 500-kHz electromagnetic field. The release profile of 5-FU from TMs was examined by using a microdialysis technique. The temperature of TMs in the tumor was effectively elevated to 42°C and maintained at this temperature, overcoming the "cooling effect" of blood flow and surrounding tissues. The release kinetics of 5-FU from TMs was successfully analyzed by physiological modeling, which allows the prediction of intratumor drug concentrations during electromagnetic field exposure under various conditions. In conclusion, this study first demonstrated an in vivo evidence for the electromagnetic field-induced thermosensitive release of a drug from TMs in a tumor with the use of microdialysis.</description><identifier>ISSN: 1061-186X</identifier><identifier>EISSN: 1029-2330</identifier><identifier>DOI: 10.3109/10611869808997865</identifier><identifier>PMID: 9771619</identifier><language>eng</language><publisher>Abington: Informa UK Ltd</publisher><subject>5-fluorouracil ; Animals ; Antimetabolites, Antineoplastic - metabolism ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; dextran magnetite ; Drug Carriers ; drug release ; Electromagnetic Fields ; electromagnetic induction heating ; Female ; Fluorouracil - blood ; Fluorouracil - metabolism ; General pharmacology ; Liposomes ; Medical sciences ; melanoma ; Melanoma, Experimental - blood ; Melanoma, Experimental - metabolism ; Mice ; Mice, Inbred C57BL ; microdialysis ; Microdialysis - methods ; Models, Biological ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Thermometers ; thermosensitive magnetoliposomes ; Tumor Cells, Cultured</subject><ispartof>Journal of drug targeting, 1998, Vol.5 (5), p.379-390</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-80d56e2fe8116366cd2586a3feae4c31b7c0f41fe56ea8206c731f12198631f53</citedby><cites>FETCH-LOGICAL-c461t-80d56e2fe8116366cd2586a3feae4c31b7c0f41fe56ea8206c731f12198631f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10611869808997865$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10611869808997865$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2413109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9771619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Viroonchatapan, Ekapop</creatorcontrib><creatorcontrib>Sato, Hitoshi</creatorcontrib><creatorcontrib>Ueno, Masaharu</creatorcontrib><creatorcontrib>Adachi, Isao</creatorcontrib><creatorcontrib>Murata, Jun</creatorcontrib><creatorcontrib>Saiki, Ikuo</creatorcontrib><creatorcontrib>Tazawa, Kenji</creatorcontrib><creatorcontrib>Horikoshi, Isamu</creatorcontrib><title>Microdialysis Assessment of 5-Fluorouracil Release from Thermosensitive Magnetoliposomes Induced by an Electromagnetic Field in Tumor-Bearing Mice</title><title>Journal of drug targeting</title><addtitle>J Drug Target</addtitle><description>Abstract
The current study was designed to evaluate the properties of thermosensitive magnetoliposomes (TMs), a new drug carrier proposed by the authors, in an electromagnetic field pertaining to their selective heating and drug release under an in vivo condition. TMs containing 5-fluorouracil (5-FU) were prepared by reverse-phase evaporation, injected into the tumor mass of B16-BL6 melanoma in mice, and selectively heated by a 500-kHz electromagnetic field. The release profile of 5-FU from TMs was examined by using a microdialysis technique. The temperature of TMs in the tumor was effectively elevated to 42°C and maintained at this temperature, overcoming the "cooling effect" of blood flow and surrounding tissues. The release kinetics of 5-FU from TMs was successfully analyzed by physiological modeling, which allows the prediction of intratumor drug concentrations during electromagnetic field exposure under various conditions. In conclusion, this study first demonstrated an in vivo evidence for the electromagnetic field-induced thermosensitive release of a drug from TMs in a tumor with the use of microdialysis.</description><subject>5-fluorouracil</subject><subject>Animals</subject><subject>Antimetabolites, Antineoplastic - metabolism</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>dextran magnetite</subject><subject>Drug Carriers</subject><subject>drug release</subject><subject>Electromagnetic Fields</subject><subject>electromagnetic induction heating</subject><subject>Female</subject><subject>Fluorouracil - blood</subject><subject>Fluorouracil - metabolism</subject><subject>General pharmacology</subject><subject>Liposomes</subject><subject>Medical sciences</subject><subject>melanoma</subject><subject>Melanoma, Experimental - blood</subject><subject>Melanoma, Experimental - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>microdialysis</subject><subject>Microdialysis - methods</subject><subject>Models, Biological</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Thermometers</subject><subject>thermosensitive magnetoliposomes</subject><subject>Tumor Cells, Cultured</subject><issn>1061-186X</issn><issn>1029-2330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEUhQdRaq3-AB-EPIhvU3MnM5kM-tKWbi20CLKCb0M2c9NNySRr7oyyf8NfbNZdCyL0KRfudw435xTFa-CnAnj3HrgEULJTXHVdq2TzpDgGXnVlJQR_upsllBn49rx4QXTPOQgJ_Kg46toWJHTHxa9bZ1IcnPZbcsTOiJBoxDCxaFlTLvwcU5yTNs6zL-hREzKb4siWa0xjJAzkJvcD2a2-CzhF7zaR4ojErsMwGxzYast0YJcezZR1fyhn2MKhH5gLbDmPMZXnqJMLdyxfgy-LZ1Z7wleH96T4urhcXnwqbz5fXV-c3ZSmljCVig-NxMqiApBCSjNUjZJaWNRYGwGr1nBbg8VMaVVxaVoBFirolMxDI06Kd3vfTYrfZ6SpHx0Z9F4HjDP10GbjWu1A2IM5KaKEtt8kN-q07YH3ux76_3rImjcH83k14vCgOASf928Pe01Ge5t0MI4esKqGnXHGPu4xF2xMo_4Zkx_6SW99TH814rErPvwjX6P209rohP19bjXkeB_5w2-0krei</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Viroonchatapan, Ekapop</creator><creator>Sato, Hitoshi</creator><creator>Ueno, Masaharu</creator><creator>Adachi, Isao</creator><creator>Murata, Jun</creator><creator>Saiki, Ikuo</creator><creator>Tazawa, Kenji</creator><creator>Horikoshi, Isamu</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>1998</creationdate><title>Microdialysis Assessment of 5-Fluorouracil Release from Thermosensitive Magnetoliposomes Induced by an Electromagnetic Field in Tumor-Bearing Mice</title><author>Viroonchatapan, Ekapop ; Sato, Hitoshi ; Ueno, Masaharu ; Adachi, Isao ; Murata, Jun ; Saiki, Ikuo ; Tazawa, Kenji ; Horikoshi, Isamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-80d56e2fe8116366cd2586a3feae4c31b7c0f41fe56ea8206c731f12198631f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>5-fluorouracil</topic><topic>Animals</topic><topic>Antimetabolites, Antineoplastic - metabolism</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>dextran magnetite</topic><topic>Drug Carriers</topic><topic>drug release</topic><topic>Electromagnetic Fields</topic><topic>electromagnetic induction heating</topic><topic>Female</topic><topic>Fluorouracil - blood</topic><topic>Fluorouracil - metabolism</topic><topic>General pharmacology</topic><topic>Liposomes</topic><topic>Medical sciences</topic><topic>melanoma</topic><topic>Melanoma, Experimental - blood</topic><topic>Melanoma, Experimental - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>microdialysis</topic><topic>Microdialysis - methods</topic><topic>Models, Biological</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Thermometers</topic><topic>thermosensitive magnetoliposomes</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Viroonchatapan, Ekapop</creatorcontrib><creatorcontrib>Sato, Hitoshi</creatorcontrib><creatorcontrib>Ueno, Masaharu</creatorcontrib><creatorcontrib>Adachi, Isao</creatorcontrib><creatorcontrib>Murata, Jun</creatorcontrib><creatorcontrib>Saiki, Ikuo</creatorcontrib><creatorcontrib>Tazawa, Kenji</creatorcontrib><creatorcontrib>Horikoshi, Isamu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of drug targeting</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Viroonchatapan, Ekapop</au><au>Sato, Hitoshi</au><au>Ueno, Masaharu</au><au>Adachi, Isao</au><au>Murata, Jun</au><au>Saiki, Ikuo</au><au>Tazawa, Kenji</au><au>Horikoshi, Isamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microdialysis Assessment of 5-Fluorouracil Release from Thermosensitive Magnetoliposomes Induced by an Electromagnetic Field in Tumor-Bearing Mice</atitle><jtitle>Journal of drug targeting</jtitle><addtitle>J Drug Target</addtitle><date>1998</date><risdate>1998</risdate><volume>5</volume><issue>5</issue><spage>379</spage><epage>390</epage><pages>379-390</pages><issn>1061-186X</issn><eissn>1029-2330</eissn><abstract>Abstract
The current study was designed to evaluate the properties of thermosensitive magnetoliposomes (TMs), a new drug carrier proposed by the authors, in an electromagnetic field pertaining to their selective heating and drug release under an in vivo condition. TMs containing 5-fluorouracil (5-FU) were prepared by reverse-phase evaporation, injected into the tumor mass of B16-BL6 melanoma in mice, and selectively heated by a 500-kHz electromagnetic field. The release profile of 5-FU from TMs was examined by using a microdialysis technique. The temperature of TMs in the tumor was effectively elevated to 42°C and maintained at this temperature, overcoming the "cooling effect" of blood flow and surrounding tissues. The release kinetics of 5-FU from TMs was successfully analyzed by physiological modeling, which allows the prediction of intratumor drug concentrations during electromagnetic field exposure under various conditions. In conclusion, this study first demonstrated an in vivo evidence for the electromagnetic field-induced thermosensitive release of a drug from TMs in a tumor with the use of microdialysis.</abstract><cop>Abington</cop><pub>Informa UK Ltd</pub><pmid>9771619</pmid><doi>10.3109/10611869808997865</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-186X |
| ispartof | Journal of drug targeting, 1998, Vol.5 (5), p.379-390 |
| issn | 1061-186X 1029-2330 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_10611869808997865 |
| source | Taylor & Francis:Master (3349 titles); MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | 5-fluorouracil Animals Antimetabolites, Antineoplastic - metabolism Antineoplastic agents Biological and medical sciences Chemotherapy dextran magnetite Drug Carriers drug release Electromagnetic Fields electromagnetic induction heating Female Fluorouracil - blood Fluorouracil - metabolism General pharmacology Liposomes Medical sciences melanoma Melanoma, Experimental - blood Melanoma, Experimental - metabolism Mice Mice, Inbred C57BL microdialysis Microdialysis - methods Models, Biological Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Thermometers thermosensitive magnetoliposomes Tumor Cells, Cultured |
| title | Microdialysis Assessment of 5-Fluorouracil Release from Thermosensitive Magnetoliposomes Induced by an Electromagnetic Field in Tumor-Bearing Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T09%3A15%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microdialysis%20Assessment%20of%205-Fluorouracil%20Release%20from%20Thermosensitive%20Magnetoliposomes%20Induced%20by%20an%20Electromagnetic%20Field%20in%20Tumor-Bearing%20Mice&rft.jtitle=Journal%20of%20drug%20targeting&rft.au=Viroonchatapan,%20Ekapop&rft.date=1998&rft.volume=5&rft.issue=5&rft.spage=379&rft.epage=390&rft.pages=379-390&rft.issn=1061-186X&rft.eissn=1029-2330&rft_id=info:doi/10.3109/10611869808997865&rft_dat=%3Cproquest_infor%3E17116485%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17116485&rft_id=info:pmid/9771619&rfr_iscdi=true |