Localization of the gene for the human serotonin 5-HT2B receptor to chromosome 2
Summary A 483 bp Bgl II/Sal I repeat free fragment was isolated from the vector containing the human serotonin 5-HT2B receptor. This fragment contained part of the coding sequence located within the last exon and the entire 3′-non-translated region. It was used to probe, by Southern blots, Pst I dig...
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| Veröffentlicht in: | Molecular membrane biology 1996, Vol.13 (1), p.29-31 |
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| container_title | Molecular membrane biology |
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| creator | Horton, Yvonne M. Lubbert, Hermann Houslay, Miles D. |
| description | Summary
A 483 bp Bgl II/Sal I repeat free fragment was isolated from the vector containing the human serotonin 5-HT2B receptor. This fragment contained part of the coding sequence located within the last exon and the entire 3′-non-translated region. It was used to probe, by Southern blots, Pst I digested DNA from a series of 20 rodent-human somatic cell hybrid lines, each of which contained different complements of human chromosomes. This 5-HT2B receptor probe showed hybridization to a 2-7 kb Pst I fragment which revealed 100% concordance with location of the gene for this 5-HT receptor variant at chromosome 2. |
| doi_str_mv | 10.3109/09687689609160571 |
| format | Article |
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A 483 bp Bgl II/Sal I repeat free fragment was isolated from the vector containing the human serotonin 5-HT2B receptor. This fragment contained part of the coding sequence located within the last exon and the entire 3′-non-translated region. It was used to probe, by Southern blots, Pst I digested DNA from a series of 20 rodent-human somatic cell hybrid lines, each of which contained different complements of human chromosomes. This 5-HT2B receptor probe showed hybridization to a 2-7 kb Pst I fragment which revealed 100% concordance with location of the gene for this 5-HT receptor variant at chromosome 2.</description><identifier>ISSN: 0968-7688</identifier><identifier>EISSN: 1464-5203</identifier><identifier>DOI: 10.3109/09687689609160571</identifier><language>eng</language><publisher>Informa UK Ltd</publisher><subject>5-HT ; 5-hydroxytryptamine ; chromosomal localization ; human chromosome 2 ; receptor ; Serotonin</subject><ispartof>Molecular membrane biology, 1996, Vol.13 (1), p.29-31</ispartof><rights>1996 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/09687689609160571$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/09687689609160571$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids></links><search><creatorcontrib>Horton, Yvonne M.</creatorcontrib><creatorcontrib>Lubbert, Hermann</creatorcontrib><creatorcontrib>Houslay, Miles D.</creatorcontrib><title>Localization of the gene for the human serotonin 5-HT2B receptor to chromosome 2</title><title>Molecular membrane biology</title><description>Summary
A 483 bp Bgl II/Sal I repeat free fragment was isolated from the vector containing the human serotonin 5-HT2B receptor. This fragment contained part of the coding sequence located within the last exon and the entire 3′-non-translated region. It was used to probe, by Southern blots, Pst I digested DNA from a series of 20 rodent-human somatic cell hybrid lines, each of which contained different complements of human chromosomes. This 5-HT2B receptor probe showed hybridization to a 2-7 kb Pst I fragment which revealed 100% concordance with location of the gene for this 5-HT receptor variant at chromosome 2.</description><subject>5-HT</subject><subject>5-hydroxytryptamine</subject><subject>chromosomal localization</subject><subject>human chromosome 2</subject><subject>receptor</subject><subject>Serotonin</subject><issn>0968-7688</issn><issn>1464-5203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNp1kEFLxDAQhYMouK7-AG_5A9WkadIEvejiukJBD-u5TNuJ7dImkmYR_fW26kXEwzAM73vD4xFyztmF4MxcMqN0rrRRzHDFZM4PyIJnKktkysQhWcx6MgH6mJyM444xlimVLchT4Wvouw-InXfUWxpbpC_okFofvo52P4CjIwYfvesclclmm97SgDW-xpnxtG6DH_zoB6TpKTmy0I949rOX5Hl9t11tkuLx_mF1UyRdKnVMlJBVbYW2kjcpyMYAZJWpGG8Yt4CqMcIaRJObCVdWIMu5TKsKtM6bnKFYkuvvv52bkg7w5kPflBHeex9sAFd3Yzk1M48p_7Qz2a9-2VuEPrY1BCx3fh_cFL383_0JimBqsg</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Horton, Yvonne M.</creator><creator>Lubbert, Hermann</creator><creator>Houslay, Miles D.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope/></search><sort><creationdate>1996</creationdate><title>Localization of the gene for the human serotonin 5-HT2B receptor to chromosome 2</title><author>Horton, Yvonne M. ; Lubbert, Hermann ; Houslay, Miles D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i258t-635bcf38f51d2a5d9aa4b9b01d01fae6d93f9ee9792586f3e07152bba887d70e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>5-HT</topic><topic>5-hydroxytryptamine</topic><topic>chromosomal localization</topic><topic>human chromosome 2</topic><topic>receptor</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horton, Yvonne M.</creatorcontrib><creatorcontrib>Lubbert, Hermann</creatorcontrib><creatorcontrib>Houslay, Miles D.</creatorcontrib><jtitle>Molecular membrane biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horton, Yvonne M.</au><au>Lubbert, Hermann</au><au>Houslay, Miles D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of the gene for the human serotonin 5-HT2B receptor to chromosome 2</atitle><jtitle>Molecular membrane biology</jtitle><date>1996</date><risdate>1996</risdate><volume>13</volume><issue>1</issue><spage>29</spage><epage>31</epage><pages>29-31</pages><issn>0968-7688</issn><eissn>1464-5203</eissn><abstract>Summary
A 483 bp Bgl II/Sal I repeat free fragment was isolated from the vector containing the human serotonin 5-HT2B receptor. This fragment contained part of the coding sequence located within the last exon and the entire 3′-non-translated region. It was used to probe, by Southern blots, Pst I digested DNA from a series of 20 rodent-human somatic cell hybrid lines, each of which contained different complements of human chromosomes. This 5-HT2B receptor probe showed hybridization to a 2-7 kb Pst I fragment which revealed 100% concordance with location of the gene for this 5-HT receptor variant at chromosome 2.</abstract><pub>Informa UK Ltd</pub><doi>10.3109/09687689609160571</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-7688 |
| ispartof | Molecular membrane biology, 1996, Vol.13 (1), p.29-31 |
| issn | 0968-7688 1464-5203 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_09687689609160571 |
| source | Taylor & Francis Journals Complete |
| subjects | 5-HT 5-hydroxytryptamine chromosomal localization human chromosome 2 receptor Serotonin |
| title | Localization of the gene for the human serotonin 5-HT2B receptor to chromosome 2 |
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