GnRH agonist analog therapy in advanced/recurrent granulosa cell tumors: Further evidence of a role of inhibin in monitoring response to treatment
Five patients with advanced ovarian granulosa cell malignancies resistant to cytoxic chemotherapy were treated with monthly subcutaneous injections of long-acting gonadotropin releasing hormone (GnRH) agonist analog. One partial response and one stabilization of the disease were observed. In three p...
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| Veröffentlicht in: | Gynecological endocrinology 1992, Vol.6 (4), p.271-274 |
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| container_title | Gynecological endocrinology |
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| creator | Kauppila, A. Bangah, M. Burgerm, H. Martikainen, H. |
| description | Five patients with advanced ovarian granulosa cell malignancies resistant to cytoxic chemotherapy were treated with monthly subcutaneous injections of long-acting gonadotropin releasing hormone (GnRH) agonist analog. One partial response and one stabilization of the disease were observed. In three patients, the tumor continued to progress. Treatment response was monitored with serum inhibin assay. Four patients had high serum inhibin concentrations at the beginning of GnRH analog treatment, while one patient had an inhibin-negative tumor. In three of four patients, serum inhibin remained relatively constant, or decreased during the first 3 months of therapy. It subsequently increased, in parallel with clinical deterioration. Further clinical trials with GnRH analogs are warranted in this malignancy in which serum inhibin appeared to be a clinically valuable tumor marker. |
| doi_str_mv | 10.3109/09513599209024990 |
| format | Article |
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One partial response and one stabilization of the disease were observed. In three patients, the tumor continued to progress. Treatment response was monitored with serum inhibin assay. Four patients had high serum inhibin concentrations at the beginning of GnRH analog treatment, while one patient had an inhibin-negative tumor. In three of four patients, serum inhibin remained relatively constant, or decreased during the first 3 months of therapy. It subsequently increased, in parallel with clinical deterioration. 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One partial response and one stabilization of the disease were observed. In three patients, the tumor continued to progress. Treatment response was monitored with serum inhibin assay. Four patients had high serum inhibin concentrations at the beginning of GnRH analog treatment, while one patient had an inhibin-negative tumor. In three of four patients, serum inhibin remained relatively constant, or decreased during the first 3 months of therapy. It subsequently increased, in parallel with clinical deterioration. Further clinical trials with GnRH analogs are warranted in this malignancy in which serum inhibin appeared to be a clinically valuable tumor marker.</description><subject>Adult</subject><subject>Female</subject><subject>Gonadotropin Releasing Hormone Agonist Analog Therapy</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - therapeutic use</subject><subject>Goserelin - therapeutic use</subject><subject>Granulosa Cell Tumor - blood</subject><subject>Granulosa Cell Tumor - drug therapy</subject><subject>Human Granulosa Cell Tumor</subject><subject>Humans</subject><subject>Inhibin</subject><subject>Inhibins - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Radioimmunoassay</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kduKFDEQhoMo67j6AF4IufKu3Zz6pN7IsgdhQZC9b9JJZSZLdzJW0rvMa_jEm3YWREQhkMD_f39Vqgh5y9kHyVl_xvqay7rvBeuZUH3PnpENV62sWNs0z8lm1atiYC_Jq5TuGONSteKEnHDVi7qTG_LzKny_pnobg0-Z6qCnuKV5B6j3B-oD1fZeBwP2DMEsiBAy3aIOyxSTpgamieZljpg-0ssFV47CvbdQEBod1RTj9Ovlw86PJa-cudTKEX3YUoS0jyEBzZFmBJ3nUuA1eeH0lODN031Kbi8vbs-vq5tvV1_Pv9xURjGeKxCgWtv1VlhRay3FyJrajK7roBvrpnYCQLlOGKu4ctIyJWvROVYgq42Tp-T9MXaP8ccCKQ-zT-uPdIC4pKGVqlNNJ4qRH40GY0oIbtijnzUeBs6GdQ3DX2sozLun8GWcwf4mjnMv-uej7oOLOOuHiJMdsj5MEV2Zr_Fpjf53_Kc_8B3oKe-MRhju4oJli-k_zT0CDs-rig</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Kauppila, A.</creator><creator>Bangah, M.</creator><creator>Burgerm, H.</creator><creator>Martikainen, H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>GnRH agonist analog therapy in advanced/recurrent granulosa cell tumors: Further evidence of a role of inhibin in monitoring response to treatment</title><author>Kauppila, A. ; Bangah, M. ; Burgerm, H. ; Martikainen, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-e2e47d89d2d25aa32b065cbf88e8b565f2ee4f82cd414f3d043528f047ddacf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Female</topic><topic>Gonadotropin Releasing Hormone Agonist Analog Therapy</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - therapeutic use</topic><topic>Goserelin - therapeutic use</topic><topic>Granulosa Cell Tumor - blood</topic><topic>Granulosa Cell Tumor - drug therapy</topic><topic>Human Granulosa Cell Tumor</topic><topic>Humans</topic><topic>Inhibin</topic><topic>Inhibins - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - blood</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Radioimmunoassay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kauppila, A.</creatorcontrib><creatorcontrib>Bangah, M.</creatorcontrib><creatorcontrib>Burgerm, H.</creatorcontrib><creatorcontrib>Martikainen, H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kauppila, A.</au><au>Bangah, M.</au><au>Burgerm, H.</au><au>Martikainen, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GnRH agonist analog therapy in advanced/recurrent granulosa cell tumors: Further evidence of a role of inhibin in monitoring response to treatment</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>1992</date><risdate>1992</risdate><volume>6</volume><issue>4</issue><spage>271</spage><epage>274</epage><pages>271-274</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><abstract>Five patients with advanced ovarian granulosa cell malignancies resistant to cytoxic chemotherapy were treated with monthly subcutaneous injections of long-acting gonadotropin releasing hormone (GnRH) agonist analog. One partial response and one stabilization of the disease were observed. In three patients, the tumor continued to progress. Treatment response was monitored with serum inhibin assay. Four patients had high serum inhibin concentrations at the beginning of GnRH analog treatment, while one patient had an inhibin-negative tumor. In three of four patients, serum inhibin remained relatively constant, or decreased during the first 3 months of therapy. It subsequently increased, in parallel with clinical deterioration. Further clinical trials with GnRH analogs are warranted in this malignancy in which serum inhibin appeared to be a clinically valuable tumor marker.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>1492583</pmid><doi>10.3109/09513599209024990</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Gynecological endocrinology, 1992, Vol.6 (4), p.271-274 |
| issn | 0951-3590 1473-0766 |
| language | eng |
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| source | Taylor & Francis; MEDLINE |
| subjects | Adult Female Gonadotropin Releasing Hormone Agonist Analog Therapy Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - therapeutic use Goserelin - therapeutic use Granulosa Cell Tumor - blood Granulosa Cell Tumor - drug therapy Human Granulosa Cell Tumor Humans Inhibin Inhibins - blood Luteinizing Hormone - blood Middle Aged Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - drug therapy Ovarian Neoplasms - blood Ovarian Neoplasms - drug therapy Radioimmunoassay |
| title | GnRH agonist analog therapy in advanced/recurrent granulosa cell tumors: Further evidence of a role of inhibin in monitoring response to treatment |
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