Beta Cell-Specific Expression of Retroviral mRNAS and Group-Specific Antigen and the Development of Beta Cell-Specific Autoimmunity in Non-Obese Diabetic Mice
Non-obese diabetic (NOD) mice spontaneously develop autoimmune type 1 diabetes. Earlier studies have shown that retroviruses appear to be associated with the development of the disease in these animals. This investigation was initiated to determine whether any retroviral genes are specifically expre...
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| Veröffentlicht in: | Autoimmunity (Chur, Switzerland) Switzerland), 1995, Vol.20 (1), p.19-24 |
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| creator | Pak, Chin Y. Jun, Hee Sook And, Millina Lee Yoon, Ji-Won |
| description | Non-obese diabetic (NOD) mice spontaneously develop autoimmune type 1 diabetes. Earlier studies have shown that retroviruses appear to be associated with the development of the disease in these animals. This investigation was initiated to determine whether any retroviral genes are specifically expressed in pancreatic beta cells from NOD mice, in contrast to their non-diabetic, parental strain, ICR mice. Host chromosomal DNAs from pancreatic islets, kidneys, hearts, and stomachs of NOD and ICR mice contained an equal amount of A-type retroviral genome (DNA); however, A-type retroviral gag, pol, and env mRNAs were detected in only the pancreatic islets from NOD mice. Furthermore, group-specific retroviral antigen (p73 of A-type-gag gene product) was found by immunofluorescent staining using anti-p73 antibody in only pancreatic beta cells from NOD mice. On the basis of these observations, we suggest that tissue and strain differences in transcription of the retroviral genome and beta cell-specific expression of A-type retroviral group-specific antigen p73 in NOD mice may be involved in the initiation of beta cell-specific autoimmunity leading to type 1 diabetes in these animals. |
| doi_str_mv | 10.3109/08916939508993335 |
| format | Article |
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Earlier studies have shown that retroviruses appear to be associated with the development of the disease in these animals. This investigation was initiated to determine whether any retroviral genes are specifically expressed in pancreatic beta cells from NOD mice, in contrast to their non-diabetic, parental strain, ICR mice. Host chromosomal DNAs from pancreatic islets, kidneys, hearts, and stomachs of NOD and ICR mice contained an equal amount of A-type retroviral genome (DNA); however, A-type retroviral gag, pol, and env mRNAs were detected in only the pancreatic islets from NOD mice. Furthermore, group-specific retroviral antigen (p73 of A-type-gag gene product) was found by immunofluorescent staining using anti-p73 antibody in only pancreatic beta cells from NOD mice. On the basis of these observations, we suggest that tissue and strain differences in transcription of the retroviral genome and beta cell-specific expression of A-type retroviral group-specific antigen p73 in NOD mice may be involved in the initiation of beta cell-specific autoimmunity leading to type 1 diabetes in these animals.</description><identifier>ISSN: 0891-6934</identifier><identifier>EISSN: 1607-842X</identifier><identifier>DOI: 10.3109/08916939508993335</identifier><identifier>PMID: 7578857</identifier><language>eng</language><publisher>Abingdon: Informa UK Ltd</publisher><subject>Animals ; Antigens, Viral - metabolism ; Autoimmunity (experimental aspects and models) ; beta cell-specific autoimmunity ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - virology ; Epitopes - genetics ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; group-specific retroviral antigens (p73 of A-type) ; Islets of Langerhans - immunology ; Islets of Langerhans - virology ; Mice ; Mice, Inbred ICR ; Mice, Inbred NOD ; non-obese diabetic (NOD) mice ; retroviral mRNAs ; Retroviridae - genetics ; Retroviridae - immunology ; Retroviridae Proteins - genetics ; Retroviridae Proteins - metabolism ; RNA, Messenger - analysis ; Species Specificity</subject><ispartof>Autoimmunity (Chur, Switzerland), 1995, Vol.20 (1), p.19-24</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-f9ff593768525e5552df3e8c48a980e72586cd70c3255858e2a60c45e92721323</citedby><cites>FETCH-LOGICAL-c376t-f9ff593768525e5552df3e8c48a980e72586cd70c3255858e2a60c45e92721323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08916939508993335$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08916939508993335$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2931395$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7578857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pak, Chin Y.</creatorcontrib><creatorcontrib>Jun, Hee Sook</creatorcontrib><creatorcontrib>And, Millina Lee</creatorcontrib><creatorcontrib>Yoon, Ji-Won</creatorcontrib><title>Beta Cell-Specific Expression of Retroviral mRNAS and Group-Specific Antigen and the Development of Beta Cell-Specific Autoimmunity in Non-Obese Diabetic Mice</title><title>Autoimmunity (Chur, Switzerland)</title><addtitle>Autoimmunity</addtitle><description>Non-obese diabetic (NOD) mice spontaneously develop autoimmune type 1 diabetes. Earlier studies have shown that retroviruses appear to be associated with the development of the disease in these animals. This investigation was initiated to determine whether any retroviral genes are specifically expressed in pancreatic beta cells from NOD mice, in contrast to their non-diabetic, parental strain, ICR mice. Host chromosomal DNAs from pancreatic islets, kidneys, hearts, and stomachs of NOD and ICR mice contained an equal amount of A-type retroviral genome (DNA); however, A-type retroviral gag, pol, and env mRNAs were detected in only the pancreatic islets from NOD mice. Furthermore, group-specific retroviral antigen (p73 of A-type-gag gene product) was found by immunofluorescent staining using anti-p73 antibody in only pancreatic beta cells from NOD mice. On the basis of these observations, we suggest that tissue and strain differences in transcription of the retroviral genome and beta cell-specific expression of A-type retroviral group-specific antigen p73 in NOD mice may be involved in the initiation of beta cell-specific autoimmunity leading to type 1 diabetes in these animals.</description><subject>Animals</subject><subject>Antigens, Viral - metabolism</subject><subject>Autoimmunity (experimental aspects and models)</subject><subject>beta cell-specific autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - virology</subject><subject>Epitopes - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>group-specific retroviral antigens (p73 of A-type)</subject><subject>Islets of Langerhans - immunology</subject><subject>Islets of Langerhans - virology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mice, Inbred NOD</subject><subject>non-obese diabetic (NOD) mice</subject><subject>retroviral mRNAs</subject><subject>Retroviridae - genetics</subject><subject>Retroviridae - immunology</subject><subject>Retroviridae Proteins - genetics</subject><subject>Retroviridae Proteins - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>Species Specificity</subject><issn>0891-6934</issn><issn>1607-842X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EKsPAB7BA8gKxCzh2HNuCzTCUglRaqQWJXeRxXhhXiZ3aTtv5Gb4VDzMUIVBZ-Un33Ov3dBF6WpKXrCTqFZGqrBVTPA-KMcbvoVlZE1HIin69j2ZbvchA9RA9ivGCEEJFXR2gA8GFlFzM0Pe3kDReQt8X5yMY21mDD2_GADFa77Dv8Bmk4K9s0D0ezk4W51i7Fh8FP42_HQuX7DdwP6W0BvwOrqD34wAubSP-8cdiSt4Ow-Rs2mDr8Il3xekKYvZavYKUkU_WwGP0oNN9hCf7d46-vD_8vPxQHJ8efVwujgvDRJ2KTnUdV3mUnHLgnNO2YyBNJbWSBATlsjatIIZRziWXQHVNTMVBUUFLRtkcvdjljsFfThBTM9ho8sbagZ9iI3I0E1X9X7DMHCe5jDkqd6AJPsYAXTMGO-iwaUrSbMtr_iove57tw6fVAO2tY99W1p_vdR2N7rugnbHxFqOKlTkuY292mHWdD4O-9qFvm6Q3vQ-_POyuLV7_YV-D7tPa6ADNhZ-Cyz3cccMPoePGmQ</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Pak, Chin Y.</creator><creator>Jun, Hee Sook</creator><creator>And, Millina Lee</creator><creator>Yoon, Ji-Won</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Beta Cell-Specific Expression of Retroviral mRNAS and Group-Specific Antigen and the Development of Beta Cell-Specific Autoimmunity in Non-Obese Diabetic Mice</title><author>Pak, Chin Y. ; Jun, Hee Sook ; And, Millina Lee ; Yoon, Ji-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-f9ff593768525e5552df3e8c48a980e72586cd70c3255858e2a60c45e92721323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antigens, Viral - metabolism</topic><topic>Autoimmunity (experimental aspects and models)</topic><topic>beta cell-specific autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 1 - virology</topic><topic>Epitopes - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>group-specific retroviral antigens (p73 of A-type)</topic><topic>Islets of Langerhans - immunology</topic><topic>Islets of Langerhans - virology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mice, Inbred NOD</topic><topic>non-obese diabetic (NOD) mice</topic><topic>retroviral mRNAs</topic><topic>Retroviridae - genetics</topic><topic>Retroviridae - immunology</topic><topic>Retroviridae Proteins - genetics</topic><topic>Retroviridae Proteins - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pak, Chin Y.</creatorcontrib><creatorcontrib>Jun, Hee Sook</creatorcontrib><creatorcontrib>And, Millina Lee</creatorcontrib><creatorcontrib>Yoon, Ji-Won</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Autoimmunity (Chur, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pak, Chin Y.</au><au>Jun, Hee Sook</au><au>And, Millina Lee</au><au>Yoon, Ji-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta Cell-Specific Expression of Retroviral mRNAS and Group-Specific Antigen and the Development of Beta Cell-Specific Autoimmunity in Non-Obese Diabetic Mice</atitle><jtitle>Autoimmunity (Chur, Switzerland)</jtitle><addtitle>Autoimmunity</addtitle><date>1995</date><risdate>1995</risdate><volume>20</volume><issue>1</issue><spage>19</spage><epage>24</epage><pages>19-24</pages><issn>0891-6934</issn><eissn>1607-842X</eissn><abstract>Non-obese diabetic (NOD) mice spontaneously develop autoimmune type 1 diabetes. Earlier studies have shown that retroviruses appear to be associated with the development of the disease in these animals. This investigation was initiated to determine whether any retroviral genes are specifically expressed in pancreatic beta cells from NOD mice, in contrast to their non-diabetic, parental strain, ICR mice. Host chromosomal DNAs from pancreatic islets, kidneys, hearts, and stomachs of NOD and ICR mice contained an equal amount of A-type retroviral genome (DNA); however, A-type retroviral gag, pol, and env mRNAs were detected in only the pancreatic islets from NOD mice. Furthermore, group-specific retroviral antigen (p73 of A-type-gag gene product) was found by immunofluorescent staining using anti-p73 antibody in only pancreatic beta cells from NOD mice. On the basis of these observations, we suggest that tissue and strain differences in transcription of the retroviral genome and beta cell-specific expression of A-type retroviral group-specific antigen p73 in NOD mice may be involved in the initiation of beta cell-specific autoimmunity leading to type 1 diabetes in these animals.</abstract><cop>Abingdon</cop><pub>Informa UK Ltd</pub><pmid>7578857</pmid><doi>10.3109/08916939508993335</doi><tpages>6</tpages></addata></record> |
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| ispartof | Autoimmunity (Chur, Switzerland), 1995, Vol.20 (1), p.19-24 |
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| source | MEDLINE; Access via Taylor & Francis |
| subjects | Animals Antigens, Viral - metabolism Autoimmunity (experimental aspects and models) beta cell-specific autoimmunity Biological and medical sciences Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - virology Epitopes - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology group-specific retroviral antigens (p73 of A-type) Islets of Langerhans - immunology Islets of Langerhans - virology Mice Mice, Inbred ICR Mice, Inbred NOD non-obese diabetic (NOD) mice retroviral mRNAs Retroviridae - genetics Retroviridae - immunology Retroviridae Proteins - genetics Retroviridae Proteins - metabolism RNA, Messenger - analysis Species Specificity |
| title | Beta Cell-Specific Expression of Retroviral mRNAS and Group-Specific Antigen and the Development of Beta Cell-Specific Autoimmunity in Non-Obese Diabetic Mice |
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